Publications by authors named "W E Floyd"
Article Synopsis
- First web contractures can arise from various causes such as nonthermal trauma, burns, congenital factors, and Dupuytren contracture.
- Mild cases may be treated with techniques like contracture release and skin grafting, while severe cases may need more complex solutions, as they create voids requiring additional coverage.
- Reconstructive options for severe cases include different flap methods, free tissue transfer, and techniques like distraction osteogenesis or pollicization for deeper webbing.
Radiation therapy (RT) is frequently used to treat cancers, including soft-tissue sarcomas. Prior studies established that the toll-like receptor 9 (TLR9) agonist cytosine-phosphate-guanine oligodeoxynucleotide (CpG) enhances the response to RT in transplanted tumors, but the mechanisms of this enhancement remain unclear. Here, we used CRISPR/Cas9 and the chemical carcinogen 3-methylcholanthrene (MCA) to generate autochthonous soft-tissue sarcomas with high tumor mutation burden.
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- - The study examines the link between TP53 genetic variants and survival outcomes after stereotactic radiosurgery (SRS) in patients with brain metastases from non-small cell lung cancer (NSCLC).
- - Researchers analyzed data from 255 patients who received SRS between 2015 and 2020, finding that 56% had a pathogenic TP53 variant, but overall survival did not significantly differ based on TP53 status.
- - There was a suggestion that patients with a TP53 variant had better freedom from local progression compared to those without, indicating the need for further research in larger studies.
Current Strengths and Weaknesses of ChatGPT as a Resource for Radiation Oncology Patients and Providers.
Int J Radiat Oncol Biol Phys
March 2024
Article Synopsis
- This study evaluates the effectiveness of ChatGPT, an AI program, in providing accurate information related to radiation oncology, including answering patient questions and summarizing significant clinical research.
- The assessment revealed that ChatGPT often produced inaccurate or incomplete information, with only 39.7% of patient question responses deemed correct and comprehensive.
- Despite the shortcomings, the study suggests that while ChatGPT is currently unreliable as a resource for patients and healthcare providers in radiation oncology, there may be potential for improvement in the future.
Purpose: Recently, the association between ATRX and a more aggressive sarcoma phenotype has been shown. We performed a retrospective study of sarcomas from an individual institution to evaluate ATRX as a prognosticator in soft tissue sarcoma. .
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