A glucocorticoid spike derails muscle repair to heterotopic ossification after spinal cord injury.

Why severe injury to the central nervous system (CNS) triggers the development of large neurogenic heterotopic ossifications (NHOs) within periarticular muscles remains unknown. We report that spinal cord injury (SCI) triggers a rapid corticosterone spike in mice, which is causal for NHO development because treatments with corticosterone or the synthetic glucocorticoid (GC) receptor (GR) agonist dexamethasone are sufficient to trigger heterotopic ossification and upregulate the expression of osteoinductive and osteogenic differentiation genes in injured muscles even without SCI. The central role for GR signaling in causing NHO is further demonstrated in mice deleted for the GR gene (Nr3c1), which no longer develop NHO after SCI.

A review of empirical treatments focused on mind-body and spiritually grounded complementary practices for moral injury among veterans.

Investigators have called for mind-body practices and spiritual and religious approaches for the treatment of moral injury in veterans. Programs and interventions that use mindfulness, meditation, spirituality, prayer, and other techniques span different academic disciplines and can be difficult for investigators and clinicians to identify but are important for those who work with veterans with moral injury. This paper reports a review of a systematic search that identified 12 empirical studies from eight databases (i.

Enhancing the Utility of the Moral Injury Experience Wheel: Manualized Applications for Diverse Contexts.

Moral injury has emerged as an important construct for understanding the distress experienced in the aftermath of a moral violation, initially among combat veterans and increasingly among other populations, such as healthcare workers and first responders. While numerous measures have been validated to assess for exposure to potentially morally injurious events and/or sequelae, additional tools are needed to facilitate nuanced discussion of the experience of moral injury in therapeutic encounters. The Moral Injury Experience Wheel (MIEW; Fleming, 2023) is an infographic instrument that is designed to elicit precise language and help differentiate feelings in an effort to process morally perplexing circumstances.

A framework for understanding the human experience of nature through cognitive mapping.

Human behavior is a key driver of the biodiversity crisis, and addressing it requires changing individual choices and actions. Yet, the same processes that imperil biodiversity (e.g.

Applying Biblical Wisdom to Trying Times: 10 Leadership Lessons for Nurses.

In the post-COVID era, examining nursing and pastoral leadership experiences with biblical examples offers helpful perspectives on how to lead in times of crisis and adversity. Reflecting on men and women of the Bible who led during crisis can encourage nurses to view our ministries through God's lens and motivate us to become stronger leaders.