Context-aware real-time semantic view expansion of intraoperative 4D OCT.

Four-dimensional microscope-integrated optical coherence tomography enables volumetric imaging of tissue structures and tool-tissue interactions in ophthalmic surgery at interactive update rates. This enables surgeons to undertake particular surgical steps under four-dimensional optical coherence tomography (4D OCT) guidance. However, current 4D OCT systems are limited by their field of view and signal quality.

Image Quality in Adaptive Optics Optical Coherence Tomography of Diabetic Patients.

: An assessment of the retinal image quality in adaptive optics optical coherence tomography (AO-OCT) is challenging. Many factors influence AO-OCT imaging performance, leading to greatly varying imaging results, even in the same subject. The aim of this study is to introduce quantitative means for an assessment of AO-OCT image quality and to compare these with parameters retrieved from the pyramid wavefront sensor of the system.

Development of a label-free, functional, molecular and structural imaging system combining optical coherence tomography and Raman spectroscopy for in vivo measurement of rat retina.

In vivo access to molecular information of retinal tissue is considered to play a critical role in enabling early diagnosis of ophthalmic and neurodegenerative diseases. The current gold standard of retina imaging, optical coherence tomography and angiography provides only the retinal morphology and blood perfusion, missing the full spectrum of molecular information. Raman spectroscopy addresses this gap while keeping the investigation non-invasive and label-free.

Optical coherence tomography angiography enables visualization of microvascular patterns in chronic venous insufficiency.

Chronic venous insufficiency (CVI) is a global health concern with significant public health and individual impact. Currently available diagnostic methods cannot visualize microvenous pathologies that have shown to result in severe forms of CVI and also affect the skin. Optical coherence tomography angiography (OCTA) may close the CVI diagnostic gap by providing a fast, label-free, and non-invasive solution to visualize cutaneous microvasculature.

Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor.

We present improvements on the adaptive optics (AO) correction method using a pyramid wavefront sensor (P-WFS) and introduce a novel approach for closed-loop focus shifting in retinal imaging. The method's efficacy is validated through adaptive optics optical coherence tomography (AO-OCT) imaging in both, healthy individuals and patients with diabetic retinopathy. In both study groups, a stable focusing on the anterior retinal layers is achieved.