Large-scale exploration of gene-gene interactions in prostate cancer using a multistage genome-wide association study.

Recent genome-wide association studies have identified independent susceptibility loci for prostate cancer that could influence risk through interaction with other, possibly undetected, susceptibility loci. We explored evidence of interaction between pairs of 13 known susceptibility loci and single nucleotide polymorphisms (SNP) across the genome to generate hypotheses about the functionality of prostate cancer susceptibility regions. We used data from Cancer Genetic Markers of Susceptibility: Stage I included 523,841 SNPs in 1,175 cases and 1,100 controls; Stage II included 27,383 SNPs in an additional 3,941 cases and 3,964 controls.

Characteristics of women requesting reversal of sterilization.

For a definition of the characteristics of women who request reversal of sterilization, 180 such women were compared with 180 women apparently satisfied with sterilization. Women who requested tubal reversal were younger at the time of sterilization, began and completed their families at an earlier age, and were of lower socioeconomic status than those who did not request reversal of sterilization. Women requesting reversal of sterilization had a significantly higher incidence of gynecologic clinic visits after and mental health clinic visits before and after sterilization.

Prolactin-producing microadenomas in pregnancy.

Fifty-four patients with evidence of a prolactin-producing pituitary microadenoma were followed through pregnancy. Obstetric complications included four spontaneous abortions, one stillbirth, and one premature delivery. Four patients developed visual defects (two with abnormal visual fields).

Amniotic fluid beta-endorphin and alpha-melanocyte--stimulating hormone immunoreactivity in normal and complicated pregnancies.

beta-Endorphin (beta-EP) and alpha-melanocyte--stimulating hormone (alpha-MSH) are members of a family of peptides which are found in the intermediate lobe of the fetal pituitary gland and placenta. In the present study, concentrations of immunoreactive beta-EP (i beta-EP) and alpha-MSH were determined by radioimmunoassay in the amniotic fluid compartment of both normal (n = 72) and complicated (n = 44) pregnancies. In normal pregnancies, there was a significant (p less than 0.

Fetal lung maturation: amniotic fluid catecholamines, phospholipids, and cortisol.

The identification of beta-adrenergic receptors in the fetal lung led us to investigate amniotic fluid catecholamine levels in relation to other indices of fetal pulmonary maturity in late pregnancies (n = 62). Significant correlations were found between the percentage of phosphatidylglycerol and concentrations of norepinephrine (r = 0.44, p less than 0.