Publications by authors named "W DeWitt"
RNA viruses like SARS-CoV-2 have a high mutation rate, which contributes to their rapid evolution. The rate of mutations depends on the mutation type (e.g.
View Article and Find Full Text PDFBackground: Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) communities experience significant health disparities related to sexual health, including sexually transmitted infections (STIs). Improved access to culturally congruent primary care and sexual health services, including HIV/STI prevention and care, are needed. We describe how we developed a new community-based LGBTQ+ primary care clinic and implemented safety-net sexual health and STI screening and care services in Providence, Rhode Island.
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- Researchers discovered that these atypical B cells provide valuable insights into antibody sequences, analyzing large-scale single-cell sequencing data that reveal widespread instances of light chain allelic inclusion.
- Machine learning models were developed to identify unique antibody sequences associated with properties like polyreactivity and mutation usage, outperforming previous antibody modeling techniques and highlighting the importance of allelic inclusion data.
Article Synopsis
- - The Cytochrome P450 family of enzymes metabolizes around 80% of small molecule drugs, but genetic variants can significantly affect how these drugs are processed, leading to risks of incorrect dosing and severe side effects.
- - Using a technique called VAMP-seq, researchers measured the protein abundance of over 7,600 single amino acid variants in CYP2C19, revealing key structural features essential for enzyme function and showcasing how variants at specific positions can impact protein levels.
- - The study also compared variants in CYP2C19 and CYP2C9, showing that while most amino acid exchanges had little effect, certain changes in substrate recognition sites diminished abundance in CYP2C19, indicating evolutionary trade-offs between stability and