Myotonic Dystrophy (DM) Burden of Disease: A Retrospective Study of Healthcare Costs and Utilization by Individuals With DM.

Introduction/aims: Healthcare utilization and costs in myotonic dystrophy (DM) are not well understood. This study describes the burden of DM and its associated costs.

Methods: We performed a retrospective study using data from a large U.

Progressive unilateral tremor associated with large confluent perirolandic juxtacortical lesions in multiple sclerosis.

Background: Multiple sclerosis (MS)-related tremor is classically attributed to infratentorial lesions.

Objective: To characterize unilateral tremor associated with perirolandic lesions in MS.

Methods: This retrospective study included Mayo Clinic patients diagnosed with MS who had: 1) Progressive unilateral tremor; and 2) Contralateral perirolandic juxtacortical T2-lesion.

MOG antibody-associated disease epidemiology in Olmsted County, USA, and Martinique.

Objectives: To report myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) epidemiology in two American regions using 2023 diagnostic criteria.

Patients And Methods: We compared age- and sex-adjusted incidence and prevalence of MOGAD per 2023 diagnostic criteria in Olmsted County (Minnesota [USA]) and Martinique (Caribbean [FR]) (01/01/2003-12/31/2018, prevalence day) using Poisson regression. Archived sera in 68-85% were available for MOG-IgG testing by live cell-based assay at Mayo Clinic.

Deep learning MRI models for the differential diagnosis of tumefactive demyelination versus -wildtype glioblastoma.

Background And Purpose: Diagnosis of tumefactive demyelination can be challenging. The diagnosis of indeterminate brain lesions on MRI often requires tissue confirmation via brain biopsy. Noninvasive methods for accurate diagnosis of tumor and non-tumor etiologies allows for tailored therapy, optimal tumor control, and a reduced risk of iatrogenic morbidity and mortality.