Publications by authors named "W D Lagreze"
Purpose: To identify baseline clinical predictors of visual outcomes six months after acute optic neuritis using data from our completed clinical neuroprotection trial (TONE study).
Design: Secondary analysis of data from the TONE study cohort (NCT01962571).
Subjects: Total of 103 patients presenting within 10 days of a first episode of acute unilateral optic neuritis as a clinically isolated syndrome with baseline high contrast visual acuity (HCVA) < 20/40 Snellen (logMAR 0.
Purpose: To investigate orthokeratology-related diurnal variations in visual acuity, contrast sensitivity, mesopic (twilight) vision, and glare sensitivity, and to verify compliance with requirements for driver licensing.
Methods: In this prospective, multicenter, controlled study, fifty myopic (range, -1.00 to -4.
Joint Anatomical, Histological, and Imaging Investigation of the Midbrain Target Region for Superolateral Medial Forebrain Bundle Deep Brain Stimulation.
Stereotact Funct Neurosurg
November 2024
Introduction: Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (slMFB) is currently being researched in clinical trials and open case series as a therapeutic option for treatment-resistant major depressive disorder and treatment-resistant obsessive-compulsive disorder (TR-OCD). There are numerous publications describing stimulation in such proximity to the ventral tegmental area (VTA) and open questions remain concerning the stimulation target and its functional environment. As of right now, we are not aware of any publications that compare the typical electrode placements with the histologically supported tractographic depiction of the target structure.
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- The study focuses on improving the diagnosis of arteritic anterior ischemic optic neuropathy (AAION) from giant cell arteritis, which can prevent vision loss, particularly when symptoms are subtle or unreliable tests are involved.
- Researchers developed a deep learning system (DLS) to differentiate between AAION and nonarteritic anterior ischemic optic neuropathy (NAION) by analyzing color fundus images from a large international dataset involving 961 eyes from 802 patients.
- The DLS demonstrated promising performance metrics, such as area under the receiver operating characteristic curve (AUC), sensitivity, specificity, and accuracy, validating its potential as a diagnostic tool during the acute phase.
Article Synopsis
- * New studies highlight the role of peripheral vision in slowing myopia, suggesting that multifocal lenses designed to create peripheral myopic defocus can help reduce the elongation of the eyeball, which is linked to worsening myopia.
- * Although these new lenses and contacts are generally safe and well-tolerated, ongoing research should focus on diverse populations and real-world application to ensure that the benefits in managing myopia are meaningful and applicable to different groups.