Publications by authors named "W D Chey"
ACG Clinical Guideline: Treatment of Helicobacter pylori Infection.
Am J Gastroenterol
September 2024
Helicobacter pylori is a prevalent, global infectious disease that causes dyspepsia, peptic ulcer disease, and gastric cancer. The American College of Gastroenterology commissioned this clinical practice guideline (CPG) to inform the evidence-based management of patients with H. pylori infection in North America.
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- The efficacy of vonoprazan-based therapies for treating infection was similar across various demographic factors like age, sex, race, and ethnicity.
- Both dual and triple therapies using vonoprazan showed consistent results compared to lansoprazole-based triple therapy.
- Factors like BMI, alcohol intake, smoking status, and adherence to the study drug did not significantly affect treatment outcomes.
Introduction: Even in the absence of inflammation, persistent symptoms in patients with Crohn's disease (CD) are prevalent and worsen quality of life. We previously demonstrated enrichment in sulfidogenic microbes in quiescent Crohn's disease patients with (qCD + S) vs without persistent GI symptoms (qCD-S). Thus, we hypothesized that sulfur metabolic pathways would be enriched in stool while differentially abundant microbes would be associated with important sulfur metabolic pathways in qCD + S.
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- The study explores Disorders of Gut Brain Interaction (DGBI), which are gastrointestinal issues linked with psychological conditions, highlighting that current diagnostic criteria (Rome IV) ignore psychological symptoms.
- Using data from the Rome Foundation Global Epidemiology Study, researchers applied latent profile models to find how individuals with GI symptoms cluster when considering both GI and psychological symptoms versus GI symptoms alone.
- Results showed a high degree of similarity in clustering, suggesting that incorporating psychological traits into DGBI classification could lead to more accurate and nuanced categorization of individuals with these disorders.