Publications by authors named "W Cutfield"
Context: Several long-acting growth hormone (LAGH) therapies have recently become available, but guidance on their usage in children with growth hormone (GH) deficiency is limited.
Methods: International experts in pediatric endocrinology were invited to join a consensus group based on their expertise in treating children with daily GH and LAGH. The group comprised 11 experts from 10 countries across the world.
An Offspring's Health Starts Before Conception and Results of the NiPPeR Randomized Trial.
Nestle Nutr Inst Workshop Ser
November 2024
Article Synopsis
- A multinational trial, NiPPeR, tested a nutritional formulation vs. a standard supplement in pregnant women and aimed to improve maternal health and pregnancy outcomes.
- The primary outcome showed no difference in gestational glycemia, but the intervention resulted in significant benefits, such as reduced preterm delivery rates and shorter conception time for overweight women.
- Overall, the study suggests that preconception nutritional interventions can positively influence both maternal health and long-term outcomes for infants, potentially reducing the risk of chronic diseases later in life.
We previously reported that a combined -inositol, probiotics, and enriched micronutrient supplement (intervention) taken preconception and in pregnancy reduced postpartum blood loss (PBL) and major postpartum hemorrhage compared with a standard micronutrient supplement (control), as secondary outcomes of the NiPPeR trial. This study aimed to identify the intervention components that may contribute to this effect. Associations of plasma concentrations of -inositol and vitamins B2, B6, B12, and D at preconception (before and after supplementation), early (~7-weeks), and late pregnancy (~28-weeks) with PBL were assessed by multiple linear regression, adjusting for site, ethnicity, preconception BMI, parity, and previous cesarean section.
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- - Fecal microbiota transplantation (FMT) is used to treat gut-related diseases, and this study investigates its effect on the phage populations in recipients after treatment.
- - Results showed that donor phages were successfully integrated into the recipients' microbiomes, making up around 34% of their phage population throughout the study period.
- - FMT not only increased the diversity and variability of phages in recipients but also shifted their overall microbial composition closer to that of the donors.