Publications by authors named "W Castro"
The energetic demands of proliferating cells during tumorigenesis require close coordination between the cell cycle and metabolism. While CDK4 is known for its role in cell proliferation, its metabolic function in cancer, particularly in triple-negative breast cancer (TNBC), remains unclear. Our study, using genetic and pharmacological approaches, reveals that CDK4 inactivation only modestly impacts TNBC cell proliferation and tumor formation.
View Article and Find Full Text PDFIntroduction: Segmental Odontomaxillary Dysplasia (SOD) is a non-hereditary, unilateral developmental anomaly recently included in the WHO's classification of head and neck tumors.
Case Presentation: Here, we report the case of an 8-year-old boy presenting with unilateral maxillary enlargement and pain without facial asymmetry. Computed tomography revealed a hypodense area in the maxillary bone with altered bone structure and osseous expansion.
Article Synopsis
- The study presents a cohort of 24 patients treated for conventional ameloblastoma, focusing on the outcomes after marginal or segmental resections over 21 years.
- Most patients were middle-aged females, with the mandible being the most affected site and a predominance of multilocular lesions.
- The results indicate a low recurrence rate (8.33%) following surgery, with patients monitored for an average of 79.25 months, suggesting that marginal/segmental resection is effective in managing this type of tumor.
Tree growth and longevity trade-offs fundamentally shape the terrestrial carbon balance. Yet, we lack a unified understanding of how such trade-offs vary across the world's forests. By mapping life history traits for a wide range of species across the Americas, we reveal considerable variation in life expectancies from 10 centimeters in diameter (ranging from 1.
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