Publications by authors named "W Cameron"

Purpose: Cardiac-related intracranial pulsatility may relate to cerebrovascular health, and this information is contained in BOLD MRI data. There is broad interest in methods to isolate BOLD pulsatility, and the current study examines a deep learning approach.

Methods: Multi-echo BOLD images, respiratory, and cardiac recordings were measured in 55 adults.

View Article and Find Full Text PDF

Background: Spontaneous cervical artery dissection (sCAD) is a leading cause of ischemic stroke in young patients. Studies using high-resolution magnetic resonance imaging and positron emission tomography have suggested vessel wall inflammation to be a pathogenic factor in sCAD. Computed tomography (CT) attenuation of perivascular adipose tissue (PVAT) is an established non-invasive imaging biomarker of inflammation in coronary arteries, with higher attenuation values reflecting a greater degree of vascular inflammation.

View Article and Find Full Text PDF

NADPH/NADP redox state supports numerous reactions related to cell growth and survival; yet the full impact is difficult to appreciate due to organelle compartmentalization of NADPH and NADP. To study glucose-stimulated NADPH production in pancreatic beta-cell organelles, we targeted the Apollo-NADP sensor by first selecting the most pH-stable version of the single-color sensor. We subsequently targeted mTurquoise2-Apollo-NADP to various organelles and confirmed activity in the cytoplasm, mitochondrial matrix, nucleus, and peroxisome.

View Article and Find Full Text PDF

Background: Mammographically detected breast arterial calcification (BAC) has been proposed as surrogate marker for coronary artery disease (CAD) in women. Epicardial adipose tissue (EAT) and peri-coronary adipose tissue (PCAT) are inflammatory fat depots linked to atherogenesis. BAC has demonstrated association with inflammation, therefore we aimed to determine the association between BAC, EAT and PCAT.

View Article and Find Full Text PDF