Detection of EGFR mutations in patients with suspected lung cancer using paired tissue-plasma testing: a prospective comparative study with plasma ddPCR assay.

Detecting EGFR mutations in plasma using droplet digital PCR (ddPCR) assay offers a promising diagnostic tool for lung cancer patients. The performance of plasma-based ddPCR assay relative to traditional EGFR mutation testing in tissue biopsies among Asian patients with suspected lung cancer remains underexplored. Consecutive patients admitted for diagnostic workup for suspected lung cancer were recruited.

Differential water deprivation tolerances of adult Rhagoletis indifferens and Rhagoletis pomonella (Diptera: Tephritidae) as a possible factor affecting their distributional abundances in Washington State, USA.

Insects that evolved in mesic regions may have difficulty establishing in xeric regions. Rhagoletis pomonella (Walsh) (Diptera: Tephritidae) was introduced into drier western North America from mesic eastern North America while Rhagoletis indifferens Curran is native to western North America. Here, we predicted that R.

Twice weekly dosing with Sebelipase alfa (Kanuma®) rescues severely ill infants with Wolman disease.

Background: Sebelipase alfa (Kanuma®) is approved for patients with Wolman disease (WD) at a dosage of 3-5 mg/kg once weekly. Survival rates in the second of two clinical trials was greater, despite recruiting more severely ill patients, probably related to higher initial and maximal doses. We aimed to evaluate the effective pharmacokinetics and pharmacodynamics of Sebelipase alfa when administered to patients with severe WD at 5 mg/kg twice weekly, an intensive regimen which was not assessed in the trials.

Sexual Selection Increases Male Behavioral Consistency in .

AbstractSexual selection has been suggested to influence the expression of male behavioral consistency. However, despite predictions, direct experimental support for this hypothesis has been lacking. Here, we investigated whether sexual selection altered male behavioral consistency in -a species with both pre- and postcopulatory sexual selection.