Targeted Conversion of Biomass into Primary Diamines via Carbon Shell-Confined Cobalt Nanoparticles.

Primary diamines are valuable yet challenging to synthesize due to issues such as product and intermediate condensation and catalyst poisoning. To address these problems, effective synthesis systems must be explored. Here, 2,5-bis(aminomethyl)furan (BAMF), a biomass-derived primary diamine, is chosen as the model for constructing such a system.

GDF15-mediated enhancement of the Warburg effect sustains multiple myeloma growth via TGFβ signaling pathway.

The Warburg effect, characterized by the shift toward aerobic glycolysis, is closely associated with the onset and advancement of tumors, including multiple myeloma (MM). Nevertheless, the specific regulatory mechanisms of glycolysis in MM and its functional role remain unclear. In this study, we identified that growth differentiation factor 15 (GDF15) is a glycolytic regulator, and GDF15 is highly expressed in MM cells and patient samples.

Discovery of Metabolic Reprogramming 2-Quinolones as Effective Antimicrobials for MRSA-Infected Wound Therapy.

To date, the abuse of antibiotics and a gradual decline in novel antibiotic discovery enlarge the threat of drug-resistant bacterial infections, especially methicillin-resistant (MRSA). Herein, inspired by the unique structures and antibacterial activities of 2-quinolones, a class of novel 2-quinolones with substituted pyridines was synthesized. Notably, compound , the derivative with a methylpyridine fragment, showed potent antibacterial and antibiofilm activities, especially for MRSA strains (MIC = 0.

Fast optimization of the emission reduction pathways of major air pollutants in China: From the perspective of different decision preferences.

To address the concern of optimization problem of China's PM control and the limitation of computational efficiencies for traditional air quality models, we developed an integrated analysis framework to efficiently establish the identification and cost-benefit assessment of PM control pathways in China by constructing a rapid PM exposure response method based on the high-order decoupled direct method (HDDM) and coupling the sequential least square algorithm (SLSQP) and health impact assessment model. Six emission reduction scenarios with varying decision preferences were analyzed. Our study provides a methodological approach for the rapid optimization of emission pathways of major air pollutants in China with flexible options in terms of objectives and constraints, fully considering the diverse differences in environmental, health, and economic impacts among different pollution sources simultaneously.

The Association Between Egg and Egg-Derived Cholesterol Consumption, and Their Change Trajectories, with Obesity Among Chinese Adults: Results from the China Health and Nutrition Survey.

As a widely consumed, nutritious, and affordable food, eggs and their derivatives' impacts on obesity remain inconclusive. In this study, we aimed to determine the association between egg and egg-derived cholesterol consumption, and their change trajectories, with obesity among Chinese adults. : Longitudinal data collected by the China Health and Nutrition Survey from 1997 to 2015 were analyzed.