Dose-related effects of eugenol: Exploring renal functionality and morphology in healthy Wistar rats.

Eugenol has pharmacological properties, but its impact on renal function is limitedly studied. Thus, this study evaluated the effects of eugenol at 10, 20, and 40 mg kg, administered via gavage for 60 days, on histological, biochemical, oxidative, and proteomic parameters in rat kidneys. Adult Wistar rats treated with 10 mg kg of eugenol had kidneys with low total antioxidant capacity, high nitric oxide content, and high percentual of blood vessels, with no damage to renal function or morphology.

Metazoan parasite community of Leporinus piau Fowler, 1941 (Anostomidae, Characiformes), an endemic freshwater fish from the Caatinga domain, Brazil.

The present study aimed to inventory the parasitic fauna of Leporinus piau from the Lima Campos weir, Salgado River basin, municipality of Icó, Ceará, Brazil. A total of 35 host specimens were collected, whereas all were parasitized by at least two metazoan taxa. A total of 2,910 parasite specimens belonging to five taxonomic groups were identified such as: Myxozoa (Henneguya sp.

Iota-Carrageenan from Marine Alga Prevents Naproxen-Induced Gastrointestinal Injury via Its Antioxidant and Anti-Inflammatory Activities.

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in therapy due to their anti-inflammatory and analgesic properties. However, their clinical use is often associated with gastrointestinal complications. Thus, this study aimed to investigate the protective effect of a sulfated iota-carrageenan isolated from the marine alga (IC-Sf) against naproxen-induced gastrointestinal injury.

Prognostic Scores for Acute Kidney Injury in Critically Ill Patients.

Background: Numerous prognostic scores have been developed and used in intensive care; however, the applicability and effectiveness of these scores in critically ill patients with acute kidney injury may vary due to the characteristics of this population.

Objective: To assess the predictive capacity of the Simplified Acute Physiology Score III (SAPS III), Sequential Sepsis-related Organ Failure Assessment (SOFA) and Nursing Activities Score (NAS) prognostic scoring systems for acute kidney injury in critically ill patients.

Methods: Cohort, prospective and quantitative study with follow-up of 141 critical patients in intensive care.

Effect of Preoperative Oral Cannabidiol-Rich Cannabis Extract on Anxiety and Postoperative Pain after Endodontic Treatment: A Double-Blind Randomized Clinical Trial.

Introduction: The aim of the present study was to evaluate the effectiveness of cannabidiol (CBD)-rich Cannabis extract in reducing anxiety and postoperative pain in patients submitted to endodontic treatment.

Methods: The study was carried out after approval by the Research Ethics Committee (Registration No. 5.