Advances in 3D printing combined with tissue engineering for nerve regeneration and repair.

The repair of nerve damage has long posed a challenge owing to limited self-repair capacity and the highly differentiated nature of nerves. While new therapeutic and pharmacologic interventions have emerged in neurology, their regenerative efficacy remains limited. Tissue engineering offers a promising avenue for overcoming the limitations of conventional treatments and increasing the outcomes of regenerative repair.

Comprehensive analysis of heat shock protein 110, 90, 70, 60 families and tumor immune microenvironment characterization in clear cell renal cell carcinoma.

Heat shock proteins (HSPs) are a kind of molecular chaperone that helps protein folding, which is closely related to cancer. However, the association between HSPs and clear cell renal clear cell carcinoma (ccRCC) is uncertain. We explored the prognostic value of HSP110, HSP90, HSP70 and HSP60 families in ccRCC and their role in tumor immune microenvironment.

White matter functional and structural alterations of spinocerebellar ataxia type 3: A longitudinal MRI study.

Widespread white matter (WM) microstructural abnormalities have been reported in patients with spinocerebellar ataxia type 3 (SCA3) using diffusion tensor imaging (DTI), whereas the ability of DTI to detect WM degeneration over short-term period remains insufficiently explored. Additionally, WM dysfunction remains entirely unknown in this disease. This study aims to investigate WM structural and functional alterations in SCA3, and provide promising progression biomarkers for short-term clinical trials.

LC-STH-13 ameliorates the progression of SLE in MRL/lpr mice by inhibiting the TLR9/NF-κB signaling pathway.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease often treated with glucocorticoids, which can lead to complications such as osteoporosis and an increased infection risk. Hence, identifying safe and effective treatment strategies is crucial. has shown promise in improving immune disorders.

Effects of polystyrene microplastics on the growth and metabolism of highland barley seedlings based on LC-MS.

Microplastics are widely present in the environment and can adversely affect plants. In this paper, the effects of different concentrations of microplastics on physiological indices and metabolites of highland barley were investigated for the first time using a metabolomics approach, and revealed the response mechanism of barley seedlings to polystyrene microplastics (PS-MPs) was revealed. The results showed that the aboveground biomass of highland barley exposed to low (10 mg/L) and medium (50 mg/L) concentrations of PS-MPs increased by 32.