Comparison of age-related decline in C57BL/6J and CB6F1J male mice.

Variability in physical resilience to aging prompts a comprehensive examination of underlying mechanisms across organs and individuals. We conducted a detailed exploration of behavioral and physiological differences between male C57BL/6J and male CB6F1J mice across various age groups (4, 12, 20, 24 months). In behavioral assays, C57BL/6J mice displayed superior performance in rotarod tasks but higher anxiety while CB6F1J mice exhibited a decline in short-term memory with age.

Creative Commons 4.0 Exploring the complex interplay between anxiety, aging, and behavior in CB6F1 and C57BL/6 mice: implications for cognitive function.

Anxiety is a pervasive emotional response that can profoundly impact well-being and cognitive function in both humans and animals. The relationship between anxiety and aging remains complex and multifaceted. To explore this relationship in more detail, an open-field photobeam system was used to quantify anxiety-related behaviors in aging CB6F1 and C57BL/6 male mice and to determine associations with aging phenotypes, including short- and long-term memory, grip strength, rotarod performance, and self-motivated wheel running.

The house cricket is an unrecognized but potentially powerful model for aging intervention studies.

Human-based research on the biology of aging poses challenges due to ethical, social, and cost considerations. Animal models offer a pragmatic alternative, although no single model fully replicates all aspects of human aging. One unexplored model for studying aging is the house cricket ().

Comparison of Age-Related Decline and Behavioral Validity in C57BL/6 and CB6F1 Mice.

Variability in physical resilience to aging prompts a comprehensive examination of underlying mechanisms across organs and individuals. We conducted a detailed exploration of behavioral and physiological differences between C57BL/6 and CB6F1 mice across various age groups. In behavioral assays, B6 mice displayed superior performance in rotarod tasks but higher anxiety while CB6F1 mice exhibited a decline in short-term memory with age.