Publications by authors named "W C Holland"
Article Synopsis
- Sphingolipids like ceramides play a significant role in high-fat diets and can influence fatty acid oxidation and intestinal stem cell (ISC) proliferation, potentially leading to cancer risk.
- The study manipulated the ceramide synthesis pathway in midgut intestinal cells to observe how changes in enzyme activities impacted cell behavior, revealing significant alterations in ISC proliferation and cell characteristics.
- Findings suggest that increased levels of saturated sphingolipids trigger inflammation in the gut, which in turn stimulates ISC proliferation through specific pro-inflammatory signals.
Article Synopsis
- BMI might not accurately reflect the risk of obesity-related cancer (ORC) because metabolic issues can exist at various BMI levels.
- A study of 20,593 postmenopausal women identified four types of metabolic health and found that those with metabolic dysfunction—regardless of weight—had an increased risk of ORC.
- The research showed that overweight and obese individuals, especially those with metabolic dysfunction, faced a higher risk of developing ORC compared to metabolically healthy individuals with normal weight.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to steatohepatitis (MASH). A key feature of the transition to MASH involves oxidative stress resulting from defects in mitochondrial oxidative phosphorylation (OXPHOS). Here, we show that pathological alterations in the lipid composition of the inner mitochondrial membrane (IMM) directly instigate electron transfer inefficiency to promote oxidative stress.
View Article and Find Full Text PDFIndividuals of Pacific ancestry suffer some of the highest rates of health disparities yet remain vastly underrepresented in genomic research, including currently available linear and pangenome references. To begin addressing this, we developed the first Pacific ancestry pangenome reference using 23 individuals with diverse Pacific ancestry. We assembled 46 haploid genomes from these 23 individuals, resulting in highly accurate and contiguous genome assemblies with an average quality value of 55.
View Article and Find Full Text PDFLike 'influencers' who achieve fame and power through social media, ceramides are low abundance members of communication platforms that have a mighty impact on their surroundings. Ceramide microdomains form within sphingolipid-laden lipid rafts that confer detergent resistance to cell membranes and serve as important signaling hubs. In cells exposed to excessive amounts of saturated fatty acids (e.
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