Publications by authors named "W C Hai"
Advances in the genetics of myasthenia gravis: insights from cutting-edge neuroscience research.
Front Med (Lausanne)
January 2025
Article Synopsis
- Myasthenia gravis (MG) is an autoimmune disorder influenced by both genetic and environmental factors, with significant insights gained from recent genome-wide and transcriptome-wide association studies.
- Recent research has uncovered new susceptibility genes and loci, highlighting the genetic complexity and subtype-specific factors associated with MG.
- The review also emphasizes the role of epigenetic mechanisms, such as DNA methylation and non-coding RNAs, in MG development, along with advancements in genetic diagnostics and biomarkers.
The decomposition of residual chitosan-based composite seed coating in kaolin under different temperatures and salinities is analyzed with a Fourier transform infrared spectroscopy (FT-IR). The degradation cycle is 28 days. The results show that a residue of the chitosan-based composite seed coating still exists in the kaolin on Day 7.
View Article and Find Full Text PDFBackground: Tumor-specific molecular probe-based imaging strategies have shown great potential for tumor diagnosis. However, the sensitivity and contrast of imaging may interfere with the complex labeling process and degradation of tumor-specific imaging probes. We sought to adapt a pretargeting strategy and an in vivo bioorthogonal reaction to improve hyaluronan (HA)-based tumor multimodal imaging diagnosis.
View Article and Find Full Text PDFBackground And Objectives: Conventional magnetic resonance imaging (MRI) used for detecting possible antibody-negative autoimmune encephalitis (AIE) often fails to meet the diagnostic requirements of this disease. Positron emission tomography (PET) with a translocator protein radioligand can help visualize microglia distribution density in inflammation-related diseases, thereby offering potentially incremental value to conventional MRI for the in vivo assessment of possible antibody-negative AIE.
Methods: In this prospective study, 15 participants diagnosed with possible antibody-negative AIE and 10 healthy controls were enrolled (ClinicalTrials.
Aims: PET myocardial perfusion imaging (MPI) is the gold standard for the noninvasive diagnosis of ischemic myocardial. Construction of F-labeled PET MPI probe showed benefits to reduce the imaging cost, and enhance the image quality and patient-friendliness.
Methods: Two F-labeled MPI probes (F-BoMPI) were developed.