Hypoglycemic and Toxic Effect of Leaf Extract on the Liver and Kidneys of Alloxan-Induced Hyperglycemic Wistar Rats.

Purpose: We investigated the hypoglycemic and toxic effect of leaf extract on the liver and kidneys of alloxan-induced hyperglycemic wistar rats.

Method: Phytochemical analysis was done. Diabetes was induced by the use of alloxan monohydrate in six groups of rats, i.

Targeting wild-type Erythrocyte receptors for Plasmodium falciparum and vivax Merozoites by Zinc Finger Nucleases In- silico: Towards a Genetic Vaccine against Malaria.

Background: Malaria causes immense human morbidity and mortality globally. The plasmodium species vivax and falciparum cause over 75 % clinical malaria cases. Until now, gene-based strategies against malaria have only been applied to plasmodium species and their mosquito-vector.

EBV, HHV8 and HIV in B cell non Hodgkin lymphoma in Kampala, Uganda.

Background: B cell non Hodgkin lymphomas account for the majority of lymphomas in Uganda. The commonest is endemic Burkitt lymphoma, followed by diffuse large-B-cell lymphoma (DLBCL). There has been an increase in incidence of malignant lymphoma since the onset of the HIV/AIDS pandemic.

An up-date on the prevalence of sickle cell trait in Eastern and Western Uganda.

Background: The first survey on sickle cell disease (SCD) done in Uganda in 1949, reported the district of Bundibugyo in Western Uganda to have the highest sickle cell trait (SCT) prevalence (45%). This is believed to be the highest in the whole world. According to the same survey, the prevalence of SCT in the districts of Mbale and Sironko in the East was 20-28%, whilst the districts of Mbarara and Ntungamo in the West had 1-5%.

Sickling and solubility tests and the peripheral blood film method for screening for sickle cell disease. [corrected].

Objective: To determine the cost benefit of screening for sickle-cell disease among infants at district health centres in Uganda using sickling, solubility tests and the peripheral blood film method.

Methods: Pilot screening services were established at district health centres. Cost benefit analysis (CBA) was performed in four scenarios: A1 - where there are no sickle-cell screening services at district health centres and all children are referred either to Mulago tertiary referral hospital or A2 - a regional hospital for haemoglobin (Hb) electrophoresis; B1 - when there are screening services at district health centres, only positive samples are taken either to Mulago Hospital or B2 - the regional hospital for confirmation using haemoglobin electrophoresis.