Evaluation of the hypothalamic-pituitary-adrenal axis and its relationship with central respiratory dysfunction in children with Prader-Willi syndrome.

Background: Children with Prader-Willi Syndrome (PWS) have been considered at risk for central adrenal insufficiency (CAI). Hypothalamic dysregulation has been proposed as a common mechanism underlying both stress-induced CAI and central respiratory dysfunction during sleep.

Objective: To evaluate CAI and sleep-related breathing disorders in PWS children.

Abnormal aortic arch morphology in Turner syndrome patients is a risk factor for hypertension.

Hypertension in Turner syndrome (TS) is a multifactorial, highly prevalent and significant problem that warrants timely diagnosis and rigorous treatment. The objective of this study was to investigate the association between abnormal aortic arch morphology and hypertension in adult TS patients. This was a single centre retrospective study in 74 adult TS patients (age 29.

Behaviour problems and relationships with family and peers during adolescence.

This study examines the relationship between (a) characteristics of adolescents' social networks, personal resources, and environmental risks; and (b) adolescents' behaviour problems. A socio-ecological perspective was used to determine whether social support and perceived conflict operate as risk or protective factors. Three samples of adolescents were studied: 63 adolescents in residential care; 29 in day treatment; and 63 who had had no contact with professional care.