Publications by authors named "W Bshara"
Article Synopsis
- Tumor-associated macrophages (TAMs) are immune cells in tumors that might help treat breast cancer, so scientists studied them in different types of breast cancer! -
- They looked at samples from mostly Black women with breast cancer to see how these macrophages relate to survival rates and other health factors! -
- The study found that women with triple-negative breast cancer had better survival rates when they had more of these macrophages, but there was no big difference in macrophage levels between Black and White women!*
Background: Cholangiocarcinomas (CCAs) are rare and aggressive malignant tumors of the biliary tract. Serotonin (5HT) has tumor-promoting effects in CCA while inhibition of 5HT synthesis can decrease tumor growth.
Methods: In this retrospective study, we evaluated the expression of 5HT and tryptophane hydroxylase-1 (TPH-1) in tumor specimens from patients treated with cisplatin plus gemcitabine (CisGem).
Photobac is a near infrared photosensitizer (PS) derived from naturally occurring bacteriochlorophyll- a, with a potential for treating a variety of cancer types (U87, F98 and C6 tumor cells in vitro). The main objective of the studies presented herein was to evaluate the efficacy, toxicity and pharmacokinetic profile of Photobac in animals (mice, rats and dogs) and submit these results to the United States Food and Drug Administration (US FDA) for its approval to initiate Phase I human clinical trials of glioblastoma, a deadly cancer disease with no long term cure. The photodynamic therapy (PDT) efficacy of Photobac was evaluated in mice subcutaneously implanted with U87 tumors, and in rats bearing C6 tumors implanted in brain.
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- During epithelial-mesenchymal transition (EMT), cancer cells change from using E-cadherin to cadherin-11 (CDH11), leading to greater invasiveness and the ability to spread to other areas.
- Researchers found that CDH11 is highly present in various human tumors and is located not just on the cell membrane but also in the cytoplasm and nucleus, raising new questions about its role.
- The study revealed that cleaved fragments of CDH11 bind to β-catenin, maintaining its activity and promoting Wnt signaling, which is crucial for tumor growth and metastasis; inhibiting CDH11 cleavage disrupts this signaling and reduces cancer cell behavior linked to progression.
Cancer cells encounter a hostile tumor microenvironment (TME), and their adaptations to metabolic stresses determine metastatic competence. Here, we show that the metabolic enzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 (PFKFB4) is induced in hypoxic tumors acquiring metabolic plasticity and invasive phenotype. In mouse models of breast cancer, genetic ablation of PFKFB4 significantly delays distant organ metastasis, reducing local lymph node invasion by suppressing expression of invasive gene signature including integrin β3.
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