Regional metabolic rate of exogenous glucose in the isoprenaline and dobutamine stimulated canine myocardium as estimated by the 2-deoxy-D[1-14C]glucose method.

The effect of beta-adrenoceptor stimulation by isoprenaline and dobutamine on the transmural distribution pattern of regional myocardial metabolic rate of exogenous glucose (RMMRGlc) was studied in the anesthetized closed chest dog using the 2-deoxy-D[1-14C]glucose method. In a previous series a lumped constant (LC) value of 0.93 +/- 0.

Distribution of myocardial glucose consumption under normal conditions and during isoprenaline and dobutamine infusion.

The regional myocardial metabolic rate of glucose (reg. MMR Gl) of the left ventricular free wall was determined applying the 2-deoxyglucose method (Sokoloff, 1977) in the anesthetized closed chest dog. Under control conditions an inhomogeneous distribution of MMR Gl was observed.

Regional glucose consumption and oxygen supply in the isolated perfused working rat heart.

Using 2-Deoxyglucose as a tracer, regional myocardial metabolic rate of glucose (MMR GL) has been determined in an isolated perfused working heart preparation. Under control conditions (n = 8) mean glucose consumption of the left ventricular wall amounted to 1.17 +/- 0.

Blood flow redistribution by dopamine in the feline gastrointestinal tract.

The effect of intravenous infusion of dopamine (10 and 25 micrograms X kg-1 X min-1 consecutively) on visceral blood flow distribution was examined in anesthetized cats using the microsphere technique and electromagnetic flowmetry. Arterial blood pressure did not change in response to dopamine infusion, but blood flow through the superior mesenteric artery, and blood flow in the mucosa-submucosa of the gastric antrum and various gut segments increased significantly. During infusion of the high dose the increase was most marked in the mucosa-submucosa of the antrum (+355%) and distal colon (+371%).

Dopamine produces vasodilation in specific regions and layers of the rabbit gastrointestinal tract.

The effect of intravenous dopamine infusion (25 and 60 micrograms per kg and min consecutively) on blood flow distribution in the splanchnic region of anesthetized rabbits was studied applying the microsphere technique. During infusion of the low dose, blood flow increased most markedly in the stomach, less in the pancreas, jejunum and descending colon, and decreased in the spleen. In the stomach the increase was confined to the mucosa-submucosa.