A novel micellular fluorogenic substrate for quantitating the activity of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma (PLCγ) enzymes.

The activities of the phospholipase C gamma (PLCγ) 1 and 2 enzymes are essential for numerous cellular processes. Unsurprisingly, dysregulation of PLCγ1 or PLCγ2 activity is associated with multiple maladies including immune disorders, cancers, and neurodegenerative diseases. Therefore, the modulation of either of these two enzymes has been suggested as a therapeutic strategy to combat these diseases.

Developing an integrated genomic selection approach beyond biomass for varietal protection and nutritive traits in perennial ryegrass (Lolium perenne L.).

Breeding target traits can be broadened to include nutritive value and plant breeder's rights traits in perennial ryegrass by using in-field regression-based spectroscopy phenotyping and genomic selection. Perennial ryegrass breeding has focused on biomass yield, but expansion into a broader set of traits is needed to benefit livestock industries whilst also providing support for intellectual property protection of cultivars. Numerous breeding objectives can be targeted simultaneously with the development of sensor-based phenomics and genomic selection (GS).

Decision making under risk: framing effects in pigeon risk preferences.

When humans face probabilistic outcomes, their choices often depend on whether the choice is framed in terms of losses or gains. In the present research, we gave pigeons a choice between risky (variable) outcomes and safe (constant) outcomes that resulted in the same net reward. In Experiment 1, in which the outcomes represented a loss, the pigeons preferred the risky alternative.

Visual alternation by pigeons: Learning to select or learning to avoid.

In the visual alternation task, pigeons learn to alternate between two stimuli (e.g., red and green) that vary randomly in location from trial to trial.