Publications by authors named "W Berrettini"
Article Synopsis
- - This study is the first large-scale examination of rare copy number variants (CNVs) in anorexia nervosa (AN), involving data from 7,414 AN cases and 5,044 controls to explore their potential genetic links to the disorder.
- - The researchers investigated both well-known syndromic CNVs and those associated with other diseases but found no significant links between these variants and AN; however, they identified 21 potential CNV regions that may play a role in AN risk, particularly in areas related to metabolic and neurodevelopmental factors.
- - Ultimately, the findings suggest that rare CNVs have a limited impact on the development of AN, aligning it with other psychiatric disorders like bipolar disorder, and indicate that
Neural processing of rewarding stimuli involves several distinct regions, including the nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons known as medium spiny neurons (MSNs). MSNs are broadly defined by dopamine receptor expression, but evidence suggests that a wider array of subtypes exist.
View Article and Find Full Text PDFBackground: Schizophrenia is a mental disorder that causes considerable morbidity, whose risk largely results from genetic factors. Setd1a is a gene implicated in schizophrenia.
Objective: To study the gene expression changes found in heterozygous Setd1a knockout mice in order to gain useful insight into schizophrenia pathogenesis.
Neural processing of rewarding stimuli involves several distinct regions, including the nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons known as medium spiny neurons (MSNs). MSNs are broadly defined by dopamine receptor expression, but evidence suggests that a wider array of subtypes exist.
View Article and Find Full Text PDFArticle Synopsis
- Bipolar disorder (BD) features disrupted sleep patterns and nerve cell loss, with lithium being a common but variably effective treatment.
- Research focused on how certain circadian genes and their interactions influence cell survival and lithium response using neurons from BD patients and regular controls.
- Findings indicated that certain gene knockdowns affected cell survival differently between lithium responders and non-responders, suggesting complex roles of circadian rhythms in BD and lithium treatment efficacy.