Correlation of lipid profile APO A1 and APO B100 in chronic periodontitis patients leading to coronary artery disease.

Background: Increased attention has been focused on the association of periodontal disease with cardio-metabolic syndrome. Although the associations are multi-factorial, very few studies have explored the role of lipoprotein Apo A1 and Apo B100 with chronic periodontitis. Additionally, obstructive sleep apnea (OSA), a chronic multi-factorial respiratory disease, consists of a temporary decrease or cessation of breath for ≥ 10 seconds and leads to a reduction in blood oxygen saturation of more than 3% to 4% and/or neurological arousal.

The role of intestinal ultrasound with colour Doppler in predicting the response to biologic therapy in inflammatory bowel disease patients.

Introduction: Inflammatory bowel disease patients are exposed to frequent procedures and hospital admissions as well as recurrent need for radiological examinations with a high risk of exposure to radiation and contrast.

Aim: Our objective was to evaluate the role of a combination of both intestinal ultrasound (IUS) and colour Doppler with different parameters for monitoring changes in inflammation over time and to reveal their potential role in the assessment of response to biologic therapy in inflammatory bowel disease (IBD) patients.

Material And Methods: Before the induction of biological therapy, IUS together with colour Doppler of the intestine was conducted.

Characterization of antimicrobial properties of TroH2A-29 peptide from golden pompano (Trachinotus ovatus).

Antimicrobial peptides (AMPs) are small, potent molecules that serve as a crucial first line of defense across a wide range of organisms, including fish. In this study, we investigated the antimicrobial properties of a novel peptide, spanning residues 52 to 80 of the full-length histone H2A protein, comprising a total of 29 amino acids. This peptide, designated as Histone H2A-29 (TroH2A-29), was derived from the golden pompano (Trachinotus ovatus) and evaluated for its activity against both Gram-positive bacteria, Lactococcus garvieae and Staphylococcus epidermidis, and Gram-negative bacteria, Vibrio alginolyticus and Vibrio harveyi.

Advancement in synthetic gene circuits engineering: An alternative strategy for microRNA imaging and disease theranostics.

Gene circuits, which are genetically engineered systems designed to regulate gene expression, are emerging as powerful tools in disease theranostics, especially in mammalian cells. This review explores the latest advances in the design and application of gene circuits for detecting and treating various diseases. Synthetic gene circuits, inspired by electronic systems, offer precise control over therapeutic gene activity, allowing for real-time, user-defined responses to pathological signals.

Design, Development, and Testing of Machine Learning Models to Estimate Properties of Friction Stir Welded Joints.

This paper estimates friction stir welded joints' ultimate tensile strength (UTS) and hardness using six supervised machine learning models (viz., linear regression, support vector regression, decision tree regression, random forest regression, K-nearest neighbour, and artificial neural network). Tool traverse speed, tool rotational speed, pin diameter, shoulder diameter, tool offset, and tool tilt are the six input parameters in the 200 datasets for training and testing the models.