Publications by authors named "W B Nagengast"
Early detection of (pre)malignant esophageal lesions is critical to improve esophageal cancer morbidity and mortality rates. In patients with advanced esophageal adenocarcinoma (EAC) who undergo neoadjuvant chemoradiation therapy, the efficacy of therapy could be optimized and unnecessary surgery prevented by the reliable assessment of residual tumors after therapy. Optical coherence tomography (OCT) provides structural images at a (sub)-cellular level and has the potential to visualize morphological changes in tissue.
View Article and Find Full Text PDFPurpose: Achieving endocrine remission by gross total resection is challenging in pituitary neuroendocrine tumours (PitNETs) with cavernous sinus invasion. This study aims to assess the safety, feasibility, and optimal dose for intraoperative fluorescence imaging as an added instrument to discriminate PitNET from surrounding tissue using bevacizumab-800CW, targeting vascular endothelial growth factor A (VEGF-A).
Methods: In part I, dose-escalation (0-4∙5-10-25 mg) was performed in 4 groups of 3 patients with PitNETs Knosp grade 3-4.
CT is the standard-of-care test for preoperative locoregional staging of colon cancer (CC) but has limited diagnostic performance. More accurate preoperative staging would guide selection among expanding patient-tailored treatment options. The purpose of this study was to evaluate through systematic review the diagnostic performance of MRI for T and N staging and that of FDG PET/CT for N staging in the locoregional staging of CC.
View Article and Find Full Text PDFThe Japanese Esophageal Society classification for prediction of superficial esophageal squamous cell neoplasia invasion depth: Validation in a Western population.
United European Gastroenterol J
October 2024
Article Synopsis
- - The JES microvessel classification was proposed for evaluating early esophageal squamous cell neoplasia (ESCN) based on the assessment of intrapapillary capillary loops, aiming to determine eligibility for endoscopic resection in Western patients.
- - A study analyzed 113 Western ESCN lesions with assessments from nine endoscopists of different experience levels, revealing good interobserver agreement among experts but only moderate agreement among residents-in-training.
- - The overall accuracy of the classification was found to be low, especially among Western endoscopists and trainees, with highlighted limitations in effectively predicting invasion depth, though experienced endoscopists showed some success in identifying superficial layers without B3 vessels.
Objective: Meningiomas are one of the most frequently occurring brain tumors and can be curatively treated with gross-total resection. A subtotal resection increases the chances of recurrence. The intraoperative identification of invisible tumor remnants by using a fluorescent tracer targeting an upregulated biomarker could help to optimize meningioma resection.
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