Publications by authors named "W B Grueber"
Mitofusin-2 (MFN2), a large GTPase residing in the mitochondrial outer membrane and mutated in Charcot-Marie-Tooth type 2 disease (CMT2A), is a regulator of mitochondrial fusion and tethering with the ER. The role of MFN2 in mitochondrial transport has however remained elusive. Like MFN2, acetylated microtubules play key roles in mitochondria dynamics.
View Article and Find Full Text PDFArticle Synopsis
- Internal sensory neurons are crucial for monitoring the body's chemical and physical state, helping maintain homeostasis and survival.
- The study focuses on tracheal dendrite (td) neurons in larvae, which are responsive to changes in oxygen and carbon dioxide levels, providing insights into how these neurons sense their environment.
- Key findings reveal that two types of guanylyl cyclases (Gyc88E/Gyc89Db) are essential for detecting low oxygen, while a specific gustatory receptor (Gr28b) is critical for sensing carbon dioxide, especially when larvae are in feeding conditions like burrowing.
When threatened by dangerous or harmful stimuli, animals engage in diverse forms of rapid escape behaviors. In larvae, one type of escape response involves C-shaped bending and lateral rolling followed by rapid forward crawling. The sensory circuitry that promotes larval escape has been extensively characterized; however, the motor programs underlying rolling are unknown.
View Article and Find Full Text PDFArticle Synopsis
- * Mitofusin-2 (MFN2), a protein involved in mitochondrial functions and linked to Charcot-Marie-Tooth disease, was found to help recruit the enzyme that acetylates alpha-tubulin, which is crucial for mitochondrial transport.
- * Mutations in MFN2 related to CMT2A may lead to axonal degeneration by hindering the process that allows the release of the acetylation enzyme, implicating disturbances in tubulin acetylation as a factor in the disease.
Synaptic connections between neurons are often formed in precise subcellular regions of dendritic arbors with implications for information processing within neurons. Cell-cell interactions are widely important for circuit wiring; however, their role in subcellular specificity is not well understood. We studied the role of axon-axon interactions in precise targeting and subcellular wiring of Drosophila somatosensory circuitry.
View Article and Find Full Text PDF