Publications by authors named "W B Giles"
Vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) act together to regulate blood pressure and systemic blood flow by appropriately adjusting blood vessel diameter in response to biochemical or biomechanical stimuli. Ion channels that are expressed in these cells regulate membrane potential and cytosolic Ca concentration ([Ca]) in response to such stimuli. The subsets of these ion channels involved in Ca signaling often form molecular complexes with intracellular molecules via scaffolding proteins.
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- - The study examines the link between TP53 genetic variants and survival outcomes after stereotactic radiosurgery (SRS) in patients with brain metastases from non-small cell lung cancer (NSCLC).
- - Researchers analyzed data from 255 patients who received SRS between 2015 and 2020, finding that 56% had a pathogenic TP53 variant, but overall survival did not significantly differ based on TP53 status.
- - There was a suggestion that patients with a TP53 variant had better freedom from local progression compared to those without, indicating the need for further research in larger studies.
Introduction: Pilonidal sinus disease (PSD) arises in the hair follicles of the gluteal cleft with many cases occurring during adolescence. Early studies of pit excision with fibrin glue closure (PEF), a minimally invasive procedure for the management of chronic PSD, suggest it is safe and effective with similar results to traditional lateralizing flap procedures (LFP), without the need for extensive tissue excision and associated complications. However, these studies lack large sample sizes and prolonged follow-up.
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