Publications by authors named "W B F Brouwer"
Background: The outbreak of COVID-19 was followed by an unprecedented package of measures to protect public health. Over 150 countries mandated school closures to reduce the risk of transmission. Decisions on whether to close schools involve trade-offs between important effects on public health, learning outcomes, well-being of children, productivity of parents.
View Article and Find Full Text PDFBackground & Aims: Metabolic dysfunction-associated steatotic liver disease (MASLD) is becoming increasingly prevalent in the general population. This study aimed at describing the cardiometabolic burden of the MASLD population and to identify patients at the highest risk of all-cause mortality and liver fibrosis.
Methods: We analysed individuals with MASLD enrolled in the National Health and Nutrition Survey (NHANES) III study (N = 3,628) and in the NHANES 2017-2020 study (n = 2,618).
Background: Obesity can result in persistent metabolic changes despite weight loss, which may affect liver health. We aimed to investigate associations between young adulthood obesity and metabolic dysfunction-associated steatotic liver disease (MASLD), at-risk steatohepatitis and increased liver stiffness measurement (LSM) in a general population setting.
Methods: We studied NHANES 2017-2020 community-dwelling participants aged > 40 years with BMI ≥ 18.
Article Synopsis
- Patients with chronic HBV infection and metabolic dysfunction-associated steatohepatitis (MASH) experience more severe liver disease than those with HBV alone, prompting research into the immune activity in these patients’ livers.
- A study using RNA sequencing compared liver biopsies from patients with only HBV, only MASH, both conditions, and healthy controls, focusing on those with minimal fibrosis to avoid confounding factors.
- The findings revealed that MASH significantly reduced critical immune activity markers, like interferon-stimulated genes and macrophage gene signatures, in HBV patients, suggesting a negative impact on antiviral responses and an increased risk of advanced fibrosis.