Publications by authors named "W Allen Moody"
Importance: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive cardiomyopathy that commonly presents with concomitant chronic kidney disease. Chronic kidney dysfunction is associated with worse outcomes, but the prognostic value of changes in kidney function over time has yet to be defined.
Objective: To assess the prognostic importance of a decline in estimated glomerular filtration rate (eGFR) in a large cohort of patients with ATTR-CM.
Article Synopsis
- The study investigates the role of beta-blockers in improving survival for patients with cardiac amyloidosis (CA), highlighting unclear efficacy and concerns about worsening heart failure symptoms.
- A systematic review and meta-analysis of 13 studies involving 4,215 CA patients concluded that beta-blocker therapy may be associated with reduced mortality, particularly in mixed ATTR-CM and AL-CM cases.
- However, the study notes significant limitations, such as a lack of information on the staging of CA, which may affect the findings' applicability.
Costello syndrome is an autosomal dominant condition caused by variants in the gene. Cardiac presentation includes valvular disease (usually valvar pulmonary stenosis), arrhythmias, and hypertrophic cardiomyopathy. To our knowledge, this is the first such report of dysplastic mitral valve associated with Costello syndrome.
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- * It analyzed data from 2,141 ATTR-CA patients, revealing that those who walked less than 350 meters on the 6MWT had a significantly higher mortality risk, with mortality rates increasing as walking distance decreased.
- * The findings suggest that monitoring changes in 6MWT performance can enhance risk assessment and disease progression understanding, offering valuable insights beyond conventional measures like N-terminal pro-B-type natriuretic peptide levels.