Publications by authors named "W Alex Vandergrift"
Article Synopsis
- Fibrous dysplasia (FD) is a nonheritable genetic condition that causes abnormal bone growth, leading to benign lesions that can sometimes become malignant, as exemplified in a case of a 61-year-old man with painful craniofacial FD.
- The patient presented with a rapidly growing mass in the skull, which MRI revealed as an extensive dysplastic mass causing significant pressure on the brain; he underwent surgery to remove the mass.
- Post-surgery pathology confirmed it as a high-grade undifferentiated pleomorphic sarcoma, leading to further treatment with chemotherapy, though the effectiveness of such treatment remains debated.
Article Synopsis
- Intracranial EEG helps identify networks associated with focal epilepsy, but how these network structures affect post-surgery seizure outcomes is not well understood.
- The study tested whether better surgical outcomes are linked to removing key brain regions (hubs) involved in seizure activity, measured by a new metric called Resection-Hub Alignment Degree (RHAD).
- Results indicated that a significant difference in RHAD was found between patients with good and bad surgical results, suggesting that analyzing network hubs offers better insights than traditional methods in predicting post-surgery epilepsy outcomes.
Objective: Laser interstitial thermal therapy (LITT) is an alternative to anterior temporal lobectomy (ATL) for the treatment of temporal lobe epilepsy that has been found by some to have a lower procedure cost but is generally regarded as less effective and sometimes results in a subsequent procedure. The goal of this study is to incorporate subsequent procedures into the cost and outcome comparison between ATL and LITT.
Methods: This single-center, retrospective cohort study includes 85 patients undergoing ATL or LITT for temporal lobe epilepsy during the period September 2015 to December 2022.
Background: The Responsive Neurostimulation (RNS) system is an implantable device for patients with drug-resistant epilepsy who are not candidates for resection of a seizure focus. As a relatively new therapeutic, the full spectrum of adverse effects has yet to be determined. A literature review revealed no previous reports of cerebral vasospasm following RNS implantation.
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