A longitudinal blended learning curriculum for bedside ultrasound education in pulmonary and critical care fellowship.

Background: There exists no standardized longitudinal curriculum for teaching bedside ultrasonography (US) in Pulmonary and Critical Care Medicine (PCCM) fellowship programs. Given the importance of mastering bedside US in clinical practice, we developed an integrated year-long US curriculum for first-year PCCM fellows.

Methods: 11 first-year PCCM fellows completed the entire seven-step Blended Learning Curriculum.

Preclinical and in silico studies of 3-benzothioyl-1-(3-hydroxy-3-phenyl-3-propyl)-1-methylthiourea: A promising agent for depression and anxiety.

The study investigated the anxiolytic, antidepressant, sedative/hypnotic and in silico molecular docking properties of the synthetic ephedrine-based derivative of thiourea, 3-benzothioyl-1-(3-hydroxy-3-phenyl-3-propyl)-1-methylthiourea. Safety profile of the compound at various doses was determined in an acute toxicity test. Results showed significant anti-anxiety effects of the compound in all mice studies.

Knowledge, Attitude, and Practice (KAP) Regarding the Use of Artificial Intelligence in Hospital Settings in Mardan, Khyber Pakhtunkhwa, Pakistan.

Background Artificial intelligence (AI) is revolutionizing healthcare globally by enhancing diagnostic accuracy, predicting patient outcomes, and enabling personalized treatment plans. However, in low- and middle-income countries (LMICs) like Pakistan, the integration of AI into healthcare is limited due to challenges such as lack of funding, provider resistance, and inadequate training. Despite these barriers, there is growing interest among healthcare providers in understanding and adopting AI technologies to improve professional efficiency.

Seven core competencies and conditions for equitable partnerships and power sharing in community-based participatory research.

Equitable health research requires actively engaging communities in producing new knowledge to advocate for their health needs. Community-based participatory research (CBPR) relies on the coproduction of contextual and grounded knowledge between researchers, programme implementers and community partners with the aim of catalysing action for change. Improving coproduction competencies can support research quality and validity.

Oxindole derivatives alleviate paracetamol-induced nephrotoxicity and hepatotoxicity: biochemical, histological, and computational expressions.

Oxindole is a nature-derived heteroaromatic nucleus with a history of preclinical uses in various conditions. In this study, oxindole derivatives, 6-chloro-3-(3-hydroxybenzylidene) indolin-2-one (3OH) and 6-chloro-3-(4-hydroxybenzylidene) indolin-2-one (4OH) were evaluated for nephroprotective and hepatoprotective effects. Paracetamol-induced nephrotoxicity and hepatotoxicity model was used in mice.