Publications by authors named "W A. Salser"
Tocotrienols are effective in lowering serum total and LDL-cholesterol levels by inhibiting the hepatic enzymic activity of beta-hydroxy-beta-methylglutaryl coenzymeA (HMG-CoA) reductase through the post-transcriptional mechanism. alpha-Tocopherol, however, has an opposite effect (induces) on this enzyme activity. Since tocotrienols are also converted to tocopherols in vivo, it is necessary not to exceed a certain dose, as this would be counter-productive.
View Article and Find Full Text PDFWe are studying novel tocotrienols, which have a number of activities that might interfere with the formation of atherosclerotic plaques, including hypocholesterolemic, antioxidant, anti-inflammatory and antiproliferation effects. This study compared the effects of alpha-tocopherol, the tocotrienol-rich fraction (TRF(25)) and didesmethyl tocotrienol (d-P(25)-T3) of rice bran on the pathogenesis of atherosclerotic lesions in C57BL/6 apolipoprotein (apo)E-deficient (-/-) mice. These mice are an excellent model because they become hyperlipidemic even when they consume a low fat diet and they develop complex atherosclerotic lesions similar to those of humans.
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- Tocotrienols and lovastatin both help lower cholesterol by inhibiting a specific enzyme, but they do so through different mechanisms.
- A study involving 28 participants showed that a tocotrienol-rich fraction combined with lovastatin significantly reduced total cholesterol and LDL-cholesterol levels more than either treatment alone, with impressive increases in the HDL/LDL ratio.
- No side effects were reported during the study, highlighting the potential of tocotrienols as effective cholesterol-lowering agents alongside traditional medications.
Article Synopsis
- DNA methylation changes often influence gene expression, but a study on six genes in HL-60 cells showed that five maintained stable methylation patterns despite significant changes in mRNA levels during granulocyte differentiation.
- The research examined a hybrid cell formed from HL-60 and B-lymphoid cells, revealing that the hybrid had a combined methylation pattern from both parent cells.
- These findings indicate that alterations in DNA methylation may not be essential for gene expression changes during terminal myeloid differentiation, and suggest that methylation patterns can be inherited independently of expression levels in hybrid cells.
Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.
Am J Hum Genet
November 1990
We recently mapped the gene for ataxia-telangiectasia group A (ATA) to chromosome 11q22-23 by linkage analysis, using the genetic markers THY1 and pYNB3.12 (D11S144). The most likely order was cent-AT-S144-THY1.
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