Publications by authors named "W A Van Vloten"

In women, acne can be successfully treated with oral contraceptives. This article focuses on the results of clinical studies on the treatment of acne with oral contraceptives. From the literature, 12 such studies could be traced over the last 10 years.

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The glucagonoma syndrome is a rare disease in which a typical skin disorder, necrolytic migratory erythema, is often one of the first presenting symptoms. Weight loss and diabetes mellitus are two other prevalent characteristics of this syndrome. Necrolytic migratory erythema belongs to the recently recognized family of deficiency dermatoses of which zinc deficiency, necrolytic acral erythema and pellagra are also members.

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Article Synopsis
  • The study investigates how UV-B exposure affects cytokine expression in the skin of patients with polymorphous light eruption (PLE) compared to healthy individuals.
  • Findings show that patients with PLE have reduced levels of specific cytokines, such as TNF-alpha and IL-4, in their UV-B-exposed skin, indicating impaired immune responses.
  • The reduction in cytokine expression may be linked to a lack of neutrophils, suggesting issues with Langerhans cell migration in the skin of patients with PLE.
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Article Synopsis
  • Ultraviolet-B radiation weakens cellular immune responses, particularly affecting Langerhans cells, which are important for skin immunity.
  • The study investigated different mouse strains with defects in DNA repair mechanisms to assess how these defects influence immune suppression and Langerhans cell loss following UV-B exposure.
  • Results indicated that while all mice experienced some degree of immunosuppression, it was primarily the mice with transcription-coupled repair defects that showed significant Langerhans cell depletion and increased sensitivity to immunosuppression.
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Urocanic acid (UCA) is a major UV-absorbing chromophore in the epidermis and has been suggested to act as one of the initiators of UV-induced immunosuppression. cis-UCA, the isomer from UCA that is formed upon UV exposure, has been shown to impair some cellular immune responses. cis-UCA levels were determined in a study in which the influence of ultraviolet B (UVB) exposure on immune responses after hepatitis B vaccination in human volunteers was established.

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