Inflammatory response to chlorhexidine, minocycline HCl and doxycycline HCl in an in vivo mouse model.

Aim: To examine the effect of locally delivered antimicrobial drugs on the inflammatory response in an in vivo mouse chamber model.

Material And Methods: Two weeks following chamber implantation, 24 BALB/c mice, in the experimental group, were given an intra-chamber challenge of heat-killed Porphyromonas gingivalis, followed immediately by injection of the specific antimicrobial drug: 2000 microg/ml chlorhexidine (CHX); 1500 microg/ml minocycline HCl;and 1500 microg/ml doxycycline HCl (concentrations achieved in the periodontal pocket with commercial controlled-release delivery systems). A second group of 24 animals received only the antimicrobial treatment without P.

IL-10 gene transfer attenuates P. gingivalis-induced inflammation.

IL-10 is an anti-inflammatory cytokine secreted by stimulated Th2 lymphocytes that can down-regulate inflammatory responses to bacterial challenge. We hypothesized that local delivery of IL-10 using gene-transfer will down-regulate inflammatory responses. We examined the effect of IL-10 plasmid injection on the local cytokine response.

Periodontal destruction is associated with coronary artery disease and periodontal infection with acute coronary syndrome.

Background: Coronary artery disease (CAD) is a highly prevalent disease with significant morbidity and mortality. Periodontal disease has been suggested to influence this disease and has been associated with CAD in some epidemiologic studies. However, this relation is still controversial.