Unleashing the potential of natural protein based nanoparticles for the delivery of therapeutic nucleic Acid: A comprehensive review.

Nucleic acid-based therapeutics represent a revolutionary approach in treating genetic disorders, offering unprecedented potential for addressing pathologies at their molecular level. However, effective cellular delivery remains a critical challenge hindering their clinical implementation. While existing delivery systems, including viral vectors and lipid nanoparticles, have shown utility, they face limitations in immunogenicity, cargo capacity, and manufacturing complexity.

A Systematic Review of the Impact of Changes to Urban Green Spaces on Health and Education Outcomes, and a Critique of Their Applicability to Inform Economic Evaluation.

Several reviews have consolidated the evidence on the impact of living near an urban green space on improving health and education outcomes and reducing mortality. However, there is limited evidence on the effectiveness or cost-effectiveness of specific improvements to these urban green spaces, which would help decision-makers make informed decisions on how to invest in urban green spaces. Therefore, this review synthesizes the impact of more specific changes to, or investments in, urban green spaces on health and education outcomes, synthesizes the cost-effectiveness of these interventions, and critiques the applicability of the evidence for an economic evaluation.

A Preliminary Study on Kinetic Analysis of Ground Reaction Force and Impulse During Gait in Patients With Total Hip Replacement and Implication for Rehabilitation.

Background: There is little research done on ground reaction forces (GRF) in terms of 3D impulses after total hip replacement (THR). This study aimed to investigate the GRFs and 3D impulses in four sub-phases of stance during gait in the patients undergoing THR.

Methods: A total of 10 pain-free THR patients and 10 healthy people were recruited.

Out-of-plane coordination of iridium single atoms with organic molecules and cobalt-iron hydroxides to boost oxygen evolution reaction.

Advancements in single-atom-based catalysts are crucial for enhancing oxygen evolution reaction (OER) performance while reducing precious metal usage. A comprehensive understanding of underlying mechanisms will expedite this progress further. Here we report Ir single atoms coordinated out-of-plane with dimethylimidazole (MI) on CoFe hydroxide (Ir/(Co,Fe)-OH/MI).