Photoprotective properties of 1,25-dihydroxyvitamin D (1,25(OH)D) to reduce UV-induced DNA damage have been established in several studies. UV-induced DNA damage in skin such as single or double strand breaks is known to initiate several cellular mechanisms including activation of poly(ADP-ribose) (pADPr) polymerase-1 (PARP-1). DNA damage from UV also increases extracellular signal-related kinase (ERK) phosphorylation, which further increases PARP activity.
View Article and Find Full Text PDFElimination of vector mosquito larvae and their breeding environments is an effective strategy in dengue disease control. Present study examined larval density and water quality in breeding habitats and container preference of dengue vectors and . Larval surveys were conducted monthly in urban, semiurban, and rural sites in Kurunegala, Sri Lanka, from January 2019 to December 2021.
View Article and Find Full Text PDFInsect Growth Regulator (IGR) novaluron is an alternative to synthetic neuro-inhibitory insecticides. Present study was designed to assess appropriate dosages of novaluron for dengue vector control. Larvae of Aedes aegypti and Ae.
View Article and Find Full Text PDFBioactive compounds in medicinal plants are more susceptible to preventing oxidative stress. Encapsulation of herbal extracts has empowered the properties and characteristics of bioactive compounds. Nanoencapsulation allows the enhancement of the stability of extracts and targeted drug delivery.
View Article and Find Full Text PDFBackground: In this study, we designed a novel genetic circuit sensitive to Cd, Zn and Pb by mimicking the CadA/CadR operon system mediated heavy metal homeostasis mechanism of Pseudomonas aeruginosa. The regular DNA motifs on natural operon were reconfigured and coupled with the enhanced Green Fluorescent Protein (eGFP) reporter to develop a novel basic NOT type logic gate CadA/CadR-eGFP to respond metal ions mentioned above. A Genetically Engineered Microbial (GEM)-based biosensor (E.
View Article and Find Full Text PDF