The use of investigator-assigned subjective or judgmental efficacy and toxicity reporting in early phase clinical trials of lung cancer treatments.

Introduction: Investigator-assigned Subjective or Judgmental Efficacy and Toxicity (ISJET) reporting represents language used to contextualize efficacy or toxicity data in clinical trials that may be inappropriate or misleading. In addition, pooling of grade 1 and 2 adverse events (AEs) may reflect a practice based on acute chemotherapy treatments rather than the expansion of chronic treatments that are now commonplace for many lung cancer patients. In this study, we set out to evaluate the use of ISJETs and combined grade 1 and 2 reporting in early phase clinical trials of lung treatments at the 2024 ASCO Annual Meeting.

Nasal lymphatic obstruction of CSF drainage as a possible cause of Alzheimer's disease and dementia.

Alzheimer's disease, the most common form of dementia among older adults, slowly destroys memory and thinking skills. In recent years, scientists have made tremendous progress in understanding Alzheimer's disease, still, they do not yet fully understand what causes the disease. This article proposes a novel etiology for Alzheimer's disease.

Cellular psychology: relating cognition to context-sensitive pyramidal cells.

'Cellular psychology' is a new field of inquiry that studies dendritic mechanisms for adapting mental events to the current context, thus increasing their coherence, flexibility, effectiveness, and comprehensibility. Apical dendrites of neocortical pyramidal cells have a crucial role in cognition - those dendrites receive input from diverse sources, including feedback, and can amplify the cell's feedforward transmission if relevant in that context. Specialized subsets of inhibitory interneurons regulate this cooperative context-sensitive processing by increasing or decreasing amplification.