Publications by authors named "W A N V Luke"
Estrogen effects in tissue are mediated in part through activation of the surface estrogen receptor GPER, a broadly expressed G protein-coupled receptor that impacts a wide range of normal and pathologic processes, including metabolism, vascular health, inflammation, and cancer. A commonly used synthetic and specific GPER agonist, named G-1, antagonizes tumors by promoting cellular differentiation and enhancing tumor immunogenicity. G-1 is a racemic compound, and since its discovery, the question of whether both enantiomers display agonist activity or the agonist activity resides primarily in a single enantiomer has never been fully resolved.
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- Anthropogenic activities release around 2,000 metric tons of mercury annually, affecting remote ecosystems and leading to inconsistencies in reported emissions and atmospheric concentrations in the Northern Hemisphere.
- Despite reported increases in mercury emissions over the past 30 years, data analysis shows a declining trend in atmospheric mercury levels, indicating that actual emissions must have decreased significantly, contradicting existing inventories.
- By using statistical modeling of data from 51 monitoring stations, the study highlights a decline in mercury concentrations from 2005 to 2020, suggesting that reductions in local emissions, rather than reemissions of legacy mercury, are primarily responsible for these trends and raising questions about the reliability of current emission inventories.
Our investigation seeks to uncover the intricate nature of mercury dynamics in the free troposphere through analysis of the isotopic composition of total gaseous elemental mercury (TGM) at the high altitude Mauna Loa Observatory (MLO, 3397 m) in Hawaii, USA. By focusing on this unique site, we aim to provide essential insights into the behavior and cycling of mercury, contributing valuable data to a deeper understanding of its global distribution and environmental impacts. Forty-eight hours of TGM sampling from January to September 2022 revealed significant variations in δHg (-1.
View Article and Find Full Text PDFThe skill of knowledge management empowers practitioners to efficiently integrate and apply knowledge in the clinical context. Current medical knowledge is vast which is beyond the human capacity to retain. Hence, modern-day learning is not just knowledge acquisition, but the organization of knowledge in a retrievable manner.
View Article and Find Full Text PDFBackground: The Canadian Anatomic Kidney Score (CAKS) is a novel 6-point grading system that standardizes the gross description of a donor kidney across 3 components-vessels, anatomy, and sticky fat. We hypothesized that the CAKS predicts allograft functional outcomes and provides additional information to the Kidney Donor Profile Index (KDPI) and histologic assessment of the donor kidney.
Methods: Single-center cohort of 145 patients who underwent renal transplantation with CAKS analysis between 2018 and 2021.