Beta-receptor blockade, physical activity, and metabolism.

The adaptation processes under physical activity are regulated through an increase in the sympathetic impulse, whereby the circulation adaptation is mediated specifically by way of beta1-receptors and the energy supply predominantly by way of beta2-receptors. The maximum performance capacity, therefore, is restricted through every form of beta-blockade. However, it follows from the receptor pattern that the mixed beta1/beta2-blockade exhibits a substantially clearer effect.