Melt Pool Simulation of Dual Laser Beam-Arc Hybrid Welding of Aluminum Alloy Using Finite Element Method.

In this study, the melt pool formation behavior of high-speed laser-arc hybrid welding of aluminum plates was simulated using finite element analysis (FEA). To evaluate the heat input efficiencies of the laser and arc, standalone laser or arc welding experiments were conducted using the same arc or laser processing parameters as those employed in hybrid welding. These experiments were also simulated using FEA to calibrate the laser and arc heat adsorption parameters.

Development of an Equivalent Analysis Model of PVB Laminated Glass for TRAM Crash Safety Analysis.

This study focuses on an equivalent model of Polyvinyl Butyral (PVB) laminated glass to simulate the Head Injury Criterion (HIC) when a pedestrian collides with a TRAM. To simulate the collision behavior that occurs when a pedestrian's head collides with PVB laminated glass, a comparison was made between the results of the widely used PLC model for PVB laminated glass modeling and an actual dynamic head impact test. The material properties of the tempered glass and PVB film used in the PLC and equivalent models were obtained via four-point bending tests and tensile tests, respectively.

GC1126A, a novel ADAMTS13 mutein, evades autoantibodies in immune-mediated thrombotic thrombocytopenic purpura.

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a rare and life-threatening blood disorder characterized by the formation of blood clots in small blood vessels. It is caused by antibodies targeting the A disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13 (ADAMTS13), which plays a role in cleaving von Willebrand factor. Most patients with iTTP have autoantibodies against specific domains of the ADAMTS13 protein, particularly the cysteine-rich and spacer domains.

Transcervical resection of myoma (TCRM): Part II.

In the part I, we have already reported the rationale, efficacy, complication, and limitation of using transcervical resection of myoma (TCRM) in the management of women with symptomatic uterine fibroids, particularly for those belonging to the International Federation of Gynaecology & Obstetrics (FIGO) myoma classification system as FIGO types 0-2. The current review as part II, the discussion will focus on the techniques, tips and complication prevention or management when TCRM is applied in the management of women with symptomatic submucosal myoma. With better understanding for TCRM-related basic knowledge, such as rationale, efficacy, complication, technique review, tips and prevention or management of complications, plus the well-training and carefully performing TCRM through preceding accurate diagnosis, and good and careful preparation and intensive monitoring during operation and using effective strategy to preventing short-term and long-term complications, TCRM can become one of most powerful strategies in offering the less traumatic injury to the uterus, and an effective and safe surgical approach in dealing with women with symptomatic submucosal myoma.

Transcervical resection of myoma (TCRM): Part I.

Uterine fibroids occur frequently in women during the reproductive age, and they are rarely associated with clinical meaning because of their benign characteristics and asymptomatic clinical presentation. Sometimes, uterine fibroids are symptomatic and associated with compression syndrome, infertility, chronic pelvic pain and heavy menstrual bleeding. All need further intervention and treatment.