Publications by authors named "W A Knape"
Article Synopsis
- The study aimed to assess the safety and effectiveness of the CellFX Percutaneous Electrode, which delivers nanosecond pulsed field ablation (nsPFA) energy to soft tissues.
- Researchers treated liver, kidney, and skeletal muscle tissues at levels three times higher than clinical standards and compared the results to traditional radiofrequency (RF) ablation.
- The findings showed successful ablation without thermal damage or collagen degeneration, and no significant negative effects on overall health were observed in lab tests before and after treatments.
Background: This study describes a unique new bioelectric approach for clearing skin lesions and illustrates the clinical and histological differences between this new method and the standards of cryoablation and Bovie radiofrequency ablation (RFA).
Objectives: To determine the advantage of stimulating regulated cell death with nanosecond pulsed electric fields over the necrosis response elicited by thermal ablation modalities.
Methods: Human abdominal skin was treated with cryoablation, Bovie RFA, and nano-pulse stimulation (NPS) therapy four times before an abdominoplasty procedure was performed to collect skin for histology.
Background And Objectives: This feasibility study describes the effects of Nano-pulse stimulation™ (NPS™) technology using the CellFX™ System on acne vulgaris of the back with the objectives of demonstrating safety and effectiveness. The CellFX System applies nanosecond pulses of electrical energy to induce highly localized regulated cell death (RCD) in the cellular structures of the targeted zone with no thermal effect on the tissue and negligible effects on surrounding non-cellular components.
Study Design/materials And Methods: Seventeen subjects were enrolled at two sites with thirteen subjects completing treatment.
Background: Nano-Pulse Stimulation™ (NPS™) therapy is a new, non-thermal bioelectric modality that applies ultrashort pulses of electric energy to trigger regulated cell death (RCD) in treated tissues. Instead of initiating necrosis by heating or freezing, NPS therapy permeabilizes intracellular organelles to activate the cell's own self-destruct pathway of programmed or regulated cell death. Unlike cryotherapeutic procedures that can both damage structural tissues and diffuse into the periphery beyond the margins of the lesion, NPS therapy only affects cells within the treated zone leaving surrounding tissue and acellular components unaffected.
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- This study evaluates the effectiveness and safety of nano-pulse stimulation (NPS) technology for treating common verrucae (warts), using short bursts of electrical energy to target and kill cells while minimizing damage to surrounding areas.
- A total of 62 subjects participated, with 195 verrucae treated using the NPS system, showing that 75.3% of treated verrucae were completely cleared within 60 days, with 54% responding after just one treatment.
- The study concluded that NPS is a safe and effective method for removing cutaneous verrucae, with minimal side effects reported and no serious adverse events observed.