Publications by authors named "W A Haller"
Article Synopsis
- Trichohepatoenteric syndrome (THES) is a rare genetic disorder linked to TTC37 or SKIV2L mutations, primarily characterized by congenital diarrhea and multisystem complications.* -
- A study of 13 UK patients diagnosed between 1996 and 2020 showed that while all required parenteral nutrition, some improved over time, with complications including gastrointestinal inflammation and high rates of monogenic inflammatory bowel disease developing by age 11.* -
- Respiratory complications remain a major concern for THES patients, with proper care being essential to reduce associated health risks and improve overall outcomes.*
Background And Aims: We have previously demonstrated high rates of chronic allograft hepatitis and fibrosis in liver transplant patients on long-term cyclosporine monotherapy. We subsequently changed practice to add low-dose prednisolone to maintenance treatment with tacrolimus post-transplant. The aim of the study was to assess the impact of the immunosuppression change on graft histopathology.
View Article and Find Full Text PDFInfluence of Sediments on Concentrations of Fluridone and Penoxsulam in the Water Column and Sediment Pore Water.
Bull Environ Contam Toxicol
November 2022
Control of invasive aquatic plants is crucial for the maintenance of chemical, biological and ecological balances in many fresh water systems. Exposure of invasive plants to herbicides used for their control may be reduced by sorption to organic matter in sediments. Since granular herbicide formulations have closer contact with sediments (compared to liquid formulations), concentrations in the water column may be much lower.
View Article and Find Full Text PDFBlockade of tumour necrosis factor (anti-TNF) is effective in patients with Crohn's Disease but has been associated with infection risk and neurological complications such as demyelination. Niemann-Pick disease Type C1 (NPC1) is a lysosomal storage disorder presenting in childhood with neurological deterioration, liver damage and respiratory infections. Some NPC1 patients develop severe Crohn's disease.
View Article and Find Full Text PDFBackground & Aims: Monogenic forms of inflammatory bowel disease (IBD) illustrate the essential roles of individual genes in pathways and networks safeguarding immune tolerance and gut homeostasis.
Methods: To build a taxonomy model, we assessed 165 disorders. Genes were prioritized based on penetrance of IBD and disease phenotypes were integrated with multi-omics datasets.