Publications by authors named "W A Griffin"
A man in his 40s was incidentally found to have a large right sided apical pleural based mass on imaging. This was further investigated with a CT-guided biopsy. Histological and immunohistochemical analysis of the tissue revealed a diagnosis of a Schwannoma: a rare, slow-growing benign nerve sheath tumour.
View Article and Find Full Text PDFBryant-Li-Bhoj syndrome (BLBS) is associated with germline mutations in the genes encoding human histone H3.3. While to date 70 H3.
View Article and Find Full Text PDFAlcohol use disorder (AUD) is the most prevalent substance use disorder but there is incomplete knowledge of the underlying molecular etiology. Here, we examined the cytosolic proteome from the nucleus accumbens core (NAcC) of ethanol drinking rhesus macaques to identify ethanol-sensitive signaling proteins. The targets were subsequently investigated using bioinformatics, genetic, and pharmacological manipulations in mouse models of ethanol drinking.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the sources of fluids and metals in porphyry systems within continental-collision settings, focusing on mercury isotopes as a potential indicator.
- The research shows positive mercury isotope values in fertile porphyries and associated mafic magmas, suggesting a connection to seawater and marine sediments, while barren rocks show negative values.
- The findings challenge existing models by proposing that the metal and fluid sources in post-subduction porphyry copper deposits are influenced more by mantle processes and oceanic plate subduction than by melting of the lower continental crust.