Publications by authors named "W A D Jack"
Background: Breast-conserving surgery, adjuvant systemic therapy, and radiotherapy are the standard of care for most women with early breast cancer. There are few reports of clinical outcomes beyond the first decade of follow-up of randomised trials comparing breast-conserving surgery with or without radiotherapy. We present a 30-year update of the Scottish Breast Conservation Trial.
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- A phase 3 randomized trial was conducted to explore the effects of omitting radiotherapy in older women (65+) with hormone receptor-positive early breast cancer after breast-conserving surgery.
- Of the 1326 participating women, those who did not receive radiotherapy had a significantly higher local breast cancer recurrence rate (9.5%) compared to those who did (0.9%), but overall survival rates were nearly the same in both groups (around 80.8%).
- The findings suggest that while omitting radiotherapy may lead to higher local recurrences, it does not impact distant recurrence or overall survival for these patients on adjuvant endocrine therapy.
Article Synopsis
- * A new saliva-based testing workflow was created that is quick and sensitive, requiring minimal preparation and equipment, and underwent optimization with a large sample size over several months.
- * The test showed high specificity (100%) and sensitivity (97%) and was successfully used in a clinical setting, identifying positive cases among employees during peak infection times.
Summary: In 2013, the Drug Supply Chain Security Act (DSCSA) was signed into law to address the growing threat of counterfeit drugs and to ensure prescription drugs remain safe and effective for patients. As part of this law, US pharmaceutical supply chain stakeholders are required to confirm the authorized status of trading partners for transactions and information disclosures, even when there is no prior business relationship. While larger Authorized Trading Partners (ATPs) have connectivity solutions in place, newer and smaller ATPs have not traditionally participated, including tens of thousands of dispensers.
View Article and Find Full Text PDFIntroduction: Excision biopsy has been the investigation of choice for patients presenting with pathological axillary lymphadenopathy without a breast abnormality. Core biopsy of nodes can provide sufficient tissue for diagnosis and has advantages in terms of morbidity and speed of diagnosis. This study evaluates the diagnostic accuracy of core biopsy in patients presenting with axillary lymphadenopathy.
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