Histology of midluteal corpus luteum and endometrium from clomiphene citrate-induced cycles.

Objective: To determine the histologic development of midluteal corpus luteum (CL) and endometrium in normal fertile women after induction of ovulation with clomiphene citrate (CC). DESIGN, PATIENTS, INTERVENTIONS: Twelve normally cycling women planning to undergo an elective tubal ligation were treated with 50 to 150 mg of CC daily on days 5 through 9 of the cycle. Luteectomy and endometrial biopsy were performed simultaneously 7 days after the urinary luteinizing hormone surge.

Luteal insufficiency: correlation between endometrial dating and integrated progesterone output in clomiphene citrate-induced cycles.

Midluteal phase endometrium was histologically dated with midcycle luteinizing hormone surge time in 29 cycles from 10 parous women during untreated cycles (control) and treatment with clomiphene citrate 50 mg and 150 mg daily on days 5 through 9. Integrated progesterone output for 7 days after luteinizing hormone surge calculated from the daily plasma progesterone levels was 66.6 +/- 9.

Placental considerations in multiple pregnancy.

This article contains a brief description of the placenta in multiple pregnancy, including a classification based on embryogenesis. The biologic and clinical importance of recognition of the different types of twin placentas is emphasized. Finally, a classification of the pathological lesions seen in these placentas, either because of the twinning process or simply associated with it, is proposed.