Publications by authors named "W A Alrefai"
Article Synopsis
- The study investigates the quality of life (QOL) and psychosocial effects on patients with various blood disorders using a cross-sectional survey format.
- Out of 417 responses, 389 were analyzed, revealing significant financial stress, social exclusion, and relationship challenges as major psychosocial impacts, with notable differences based on age and type of disorder.
- The findings highlight a strong need for tailored treatment plans that address both physical and mental health support, awareness, and financial assistance due to the observed issues with social exclusion and patient awareness.
Background & Aims: Putative anion transporter-1 (PAT1, SLC26A6) plays a key role in intestinal oxalate and bicarbonate secretion. PAT1 knockout (PKO) mice exhibit hyperoxaluria and nephrolithiasis. Notably, diseases such as inflammatory bowel disease are also associated with higher risk of hyperoxaluria and nephrolithiasis.
View Article and Find Full Text PDFSerotonin transporter (SERT) deficiency has been implicated in metabolic syndrome, intestinal inflammation, and microbial dysbiosis. Interestingly, changes in microbiome metabolic capacity and several alterations in host gene expression, including lipid metabolism, were previously observed in SERT mice ileal mucosa. However, the precise host or microbial metabolites altered by SERT deficiency that may contribute to the pleiotropic phenotype of SERT KO mice are not yet understood.
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- Diet-microbiota interactions are significant in inflammatory bowel diseases (IBD), with the aryl hydrocarbon receptor (AhR) playing a key role in metabolic regulation and inflammation.
- A study found that feeding mice I3C, a compound in cruciferous vegetables, helped reduce inflammation and improve gut microbiota balance, while a diet lacking AhR ligands led to increased inflammation and mortality.
- Results indicate that I3C can protect against chronic intestinal inflammation and restore gut health by positively influencing epithelial and microbiota status in models of IBD.
Background: Alcohol-Associated Liver Disease (ALD) is a leading cause of liver mortality. Mechanisms responsible for severe ALD and the roles of gut microbiota are not fully understood. Multi-omics tools have enabled a better understanding of metabolic alterations and can aid in identifying metabolites as biomarkers for severe ALD.
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