Modulation of long-term memory by delayed administration of the amide of L-pyroglutamyl-D-alanine, a nootropic agent, in spaced and massed training in rats.

The effects of the nootropic agent L-pyroglutamyl-D-alanine amide (given at a dose of 0.5 mg/kg i.p.

[Modulation of the long-term memory by delayed administration of the nootropic agent L-pyroglutamyl-D-alaninamide during spaced and massed training of rats].

L-pyroglutamyl-D-alanine amide significantly enhanced freezing response in the group of rats with massed training and reduced it in the group with spaced training. The control animals revealed a higher freezing response with the spaced training. No differences occurred between the groups in a cue test.

[Immune disorders in patients with purulent necrotic complications of erysipelas].

There were examined 106 patients with purulent-necrotic complications (PNC) of erysipelas and 102 patients without PNC. Significant disorders of the immune status were revealed: the reduction of T-lymphocytes quantity, their subpopulational content dysbalance, the rise of level of a middle- and small-molecular immune complexes. In patients with PNC the immunocorrection conduction is expedient.

[Laboratory methods of prognostication in suppurative complications of erysipelas inflammation].

The dynamics of the leukocyte index of intoxication (LII) and the blood-cell index (BCI) was studied in 2756 patients with erysipelas. Both indexes, raised at the height of the disease, are lowering under the therapy influence. At the purulent-inflammatory complications beginning the LII and BCI level remains high or raises 2-3 days before occurrence of clinical signs of complication.

[Metabolic disorders in erysipelas patients with concomitant diabetes mellitus].

106 patients with erysipelas against the background of manifest diabetes mellitus without pus-inflammatory complications, 102 patients with erysipelas concurrent with diabetes mellitus having pus-necrotic processes and 123 patients with erysipelas without diabetes mellitus (control group) were studied. It has been proved that kallekriin-kinin and sympatho-adrenaline system indices and prostaglandine level are changing depending on the pathological process degree. The most expressed metabolic disorders were found in case of erysipelas pus-necrotic complications against the background of decompensated diabetes mellitus.

[Research on xenobiotic metabolism for assessing the quality of protein-containing products from plant raw material produced through biotechnology methods].

Activity of microsomal hydroxylation and conjugation enzymes was studied in the liver of rats that received food concentrate of protein from sunflower groats (SPC) produced in the USSR, and soya protein isolate (SPI) produced by Ralston Purina, USA. SPC consumption during 3 months was attended by elevation of cytochrome-450 content, and activity of microsomal hydroxylation and uridinephosphate-glucuroniltransferase (UDP-GT) in hepatic microsomes, that may evidence the presence in SPC of chemical compounds of natural origin, or chemical modification of the own amino-acid products. SPI did not influence activity of microsomal hydroxylation enzymes, but it raised UDP-GT activity.