How Oxygen Deficiency and Its Ordering Control Electrical Conductivity in Sr Ca FeO Perovskites as Related to Water Oxidation Electrocatalysis.

We report on the analysis of oxygen vacancies (OVs) content and ordering of Sr Ca FeO perovskites and explain how OVs change the electrical conductivity and oxygen evolution catalytic activity of these compounds. The structure and OV content are tuned by controlling the -site composition and the reaction atmosphere. X-ray diffraction (XRD) and thermogravimetric analysis (TGA) are used to identify the crystal structures and to quantify bulk oxygen vacancy contents.

Determination of the mean duration of recent infection and false recency rate for the HIV triplex multiplex bead assay.

Background: We developed the HIV Triplex multiplex bead assay to identify and serotype HIV infection with high sensitivity and specificity; and distinguish recent from long-term HIV-1 infections. It can facilitate accurate incidence estimation, while reducing the number of tests and blood collected, which is highly desirable for use in future studies and surveys. Using previously collected, treatment-naive longitudinal seroconversion HIV-1 positive panels and specimens from individuals infected for >12 months, we determined the assay's mean duration of recent infection (MDRI) and false-recency rate (FRR) respectively, at various mean fluorescent intensity (MFI) cutoffs.

Biogenic and Anthropogenic Secondary Organic Aerosols Become Fluorescent after Highly Acidic Aging.

Primary biological aerosol particles (PBAPs) and secondary organic aerosol (SOA) both contain organic compounds that share similar chemical and optical properties. Fluorescence is often used to characterize PBAPs; however, this may be hindered due to interferences from fluorophores in SOA. Despite extensive efforts to understand the aging of SOA under elevated particle acidity conditions, little is known about how these processes affect the fluorescence of SOA and thereby their interference with the measurements of PBAPs.

Continuous quality evaluation of the Asanté rapid test for recent infection for robust kit lot quality verification.

The Sedia Biosciences Asanté rapid test for recent infection (RTRI) can identify HIV infections and characterize HIV-1 as recent or long-term infection via the positive verification (V) line and long-term line (LT) line, respectively. Tracking with Recency Assays to Control the Epidemic (TRACE) program uses RTRI assays. Successful implementation of TRACE requires high-quality test performance.

Assessing 2D visual encoding of 3D spatial connectivity.

When visualizing complex data, the layout method chosen can greatly affect the ability to identify outliers, spot incorrect modeling assumptions, or recognize unexpected patterns. Additionally, visual layout can play a crucial role in communicating results to peers. In this paper, we compared the effectiveness of three visual layouts-the adjacency matrix, a half-matrix layout, and a circular layout-for visualizing spatial connectivity data, e.

Temporal relationship between levetiracetam nonadherence and breakthrough seizures in a preclinical model of temporal lobe epilepsy.

Objective: Poor medication adherence remains a concern for individuals managing their epilepsy with antiseizure medicines (ASMs); however, ethical concerns around withholding medication make it impossible to study the causal relationship between missed doses and seizures in patients. Previous preclinical studies from our group suggest that mechanistically distinct ASMs have varying degrees of forgiveness when a dose is missed. However, with only a few ASMs studied in the context of nonadherence, we sought to expand on previous work to understand the relationship between levetiracetam (LEV) nonadherence and breakthrough seizures.

Perampanel's forgiveness factor in a variable medication adherence paradigm in a rat model of chronic epilepsy.

Background: Poor medication adherence contributes to increased morbidity and mortality in patients with epilepsy and may be under-addressed in clinical practice. Ethical concerns make it impossible to study the impact of medication nonadherence in clinical trials, but our previous work emphasizes the importance of using preclinical approaches to address these questions. With over 30 clinically available antiseizure medicines (ASM's), it remains an important question to understand the relationship between poor adherence and seizure incidence across mechanistically distinct ASM's, including the broad-spectrum ASM, perampanel (PER).

Corrigendum: Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT).

[This corrects the article DOI: 10.3389/fnins.2023.

Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT).

Background: We proposed a Phase I dose escalation trial to assess the safety of allogeneic human amniotic epithelial cells (hAECs) in stroke patients with a view to informing the design for a Phase II trial.

Methods: The design is based on 3 + 3 dose escalation design with additional components for measuring MR signal of efficacy as well as the effect of hAECs (2-8 × 10/kg, i.v.

Electronic Cigarettes: an Overlooked Tool to Alleviate Disparities in Tobacco Use Disorder Among People with Mental Health and Substance Use Disorders.

The remarkable decline in cigarette smoking since 1964 has plateaued; approximately 12.5% of Americans still smoke. People who continue to smoke are largely members of marginalized groups, such as people with behavioral health conditions (BHC), encompassing both mental health and substance use disorders.

Relevance of force-velocity and change of direction assessments for the ranking position in elite junior tennis players.

Purpose: This study aimed to correlate sprint mechanical parameters (SMP) of a linear sprint (LS) and a tennis specific modified 505 (Tm505) change of direction (CoD) test obtained with a motorized resistance device (MRD) to the current tennis ranking position (RP).

Methods: 107 male and 86 female elite junior tennis players nationally ranked in the German Tennis Federation between 10 and 18 years participated in the study. According to their age at peak height velocity (PHV), players were divided into pre-PHV, circa-PHV, and post-PHV groups.

Effectiveness and Kinematic Analysis of Initial Step Patterns for Multidirectional Acceleration in Team and Racquet Sports.

The ability for quick multidirectional accelerations is crucial for athletic performance in team and racquet sports. So far, there has been little research dedicated to different initial step patterns usually applied by players. Therefore, the present study investigated the kinematic characteristics and effectiveness of the following step patterns: Jab Step (JS), Pivot Step (PS), Gravity Step (GS) and Counter Step (CS).

Optimal Echocardiographic Parameters to Improve the Diagnostic Yield of Tc-99m-Bone Avid Tracer Cardiac Scintigraphy for Transthyretin Cardiac Amyloidosis.

Background: Echocardiographic deformation-based ratios and novel multi-parametric scores have been suggested to discriminate transthyretin cardiac amyloidosis (ATTR-CM) from other causes of increased left ventricular wall thickness among patients referred for ATTR-CM evaluation. Their relative predictive accuracy has not been well studied. We sought to (1) identify echocardiographic parameters predictive of ATTR-CM and (2) compare the diagnostic accuracy of these parameters in patients with suspected ATTR-CM referred for technetium-99m-pyrophosphate scintigraphy.

Novel Therapeutics for Anthracycline Induced Cardiotoxicity.

Anthracyclines remain an essential component of the treatment of many hematologic and solid organ malignancies, but has important implications on cardiovascular disease. Anthracycline induced cardiotoxicity (AIC) ranges from asymptomatic LV dysfunction to highly morbid end- stage heart failure. As cancer survivorship improves, the detection and treatment of AIC becomes more crucial to improve patient outcomes.

Multilayered regulations of alternative splicing, NMD, and protein stability control temporal induction and tissue-specific expression of TRIM46 during axon formation.

The gene regulation underlying axon formation and its exclusiveness to neurons remains elusive. TRIM46 is postulated to determine axonal fate. We show Trim46 mRNA is expressed before axonogenesis, but TRIM46 protein level is inhibited by alternative splicing of two cassette exons coupled separately to stability controls of Trim46 mRNA and proteins, effectively inducing functional knockout of TRIM46 proteins.

Temporal trends in disease-specific causes of cardiovascular mortality amongst patients with cancer in the USA between 1999 and 2019.

Aims: We report disease-specific cardiovascular causes of mortality among cancer patients in the USA between 1999 and 2019, considering temporal trends by age, sex, and cancer site.

Methods And Results: We used the Multiple Cause of Death database, accessed through the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research resource. We included 629 308 decedents with cardiovascular disease (CVD) recorded as the primary cause of death and active malignancy listed as a contributing cause of death.

Genomic Insights on Variation Underlying Capsule Expression in Meningococcal Carriage Isolates From University Students, United States, 2015-2016.

In January and February 2015, serogroup B (NmB) outbreaks occurred at two universities in the United States, and mass vaccination campaigns using MenB vaccines were initiated as part of a public health response. Meningococcal carriage evaluations were conducted concurrently with vaccination campaigns at these two universities and at a third university, where no NmB outbreak occurred. Meningococcal isolates ( = 1,514) obtained from these evaluations were characterized for capsule biosynthesis by whole-genome sequencing (WGS).

Immune Checkpoint Therapies and Atherosclerosis: Mechanisms and Clinical Implications: JACC State-of-the-Art Review.

Immune checkpoint inhibitor therapy has revolutionized the treatment of advanced malignancies in recent years. Numerous reports have detailed the myriad of possible adverse inflammatory effects of immune checkpoint therapies, including within the cardiovascular system. However, these reports have been largely limited to myocarditis.

Quality of life after stroke: a longitudinal analysis of a cluster randomized trial.

Purpose: Health-related quality of life (QoL) is poor after stroke, but may be improved with comprehensive care plans. We aimed to determine the effects of an individualized management program on QoL in people with stroke or transient ischemic attack (TIA), describe changes in QoL over time, and identify variables associated with QoL.

Methods: This was a multicenter, cluster randomized controlled trial with blinded assessment of outcomes and intention-to-treat analysis.

Sleep fragmentation and decreased REM sleep in a primate model of diurnal cortical seizures.

Many people with epilepsy suffer from comorbid sleep disorders and sleep fragmentation. While the disruptive nature of seizures on sleep is well documented, it is unclear how diurnal seizures impact sleep quality and for how long these changes persist during the following nights. To better understand this relationship, the sleep architecture of two rhesus macaques were studied before and several nights after penicillin-induced diurnal seizures.

Physical determinants, intercorrelations, and relevance of movement speed components in elite junior tennis players.

Movement speed is considered essential for success in elite tennis. The aim of the present study was to develop a model of movement speed components and quantify their age - and gender-related relevance for tennis performance. Physical testing data obtained from 1,434 nationally ranked junior squad tennis players were divided according to the age at peak height velocity (YPHV) into two age groups (pre-PHV: n=103 girls, 11.

Topographic Evolution of Anterior Cerebral Artery Infarction and Its Impact on Motor Impairment.

Introduction: Motor deficit is common following anterior cerebral artery (ACA) stroke. This study aimed to determine the impact on the motor outcome, given the location of descending corticofugal fiber tracts (from the primary motor cortex [M1], dorsal and ventral premotor area [PMdv], and supplementary motor area [SMA]) and the regional variations in collateral support of the ACA territory.

Methods: Patients with ACA vessel occlusion were included.

Modeling Optimal Laboratory Testing Strategies for Bacterial Meningitis Surveillance in Africa.

Since 2010, the introduction of an effective serogroup A meningococcal conjugate vaccine has led to the near-elimination of invasive Neisseria meningitidis serogroup A disease in Africa's meningitis belt. However, a significant burden of disease and epidemics due to other bacterial meningitis pathogens remain in the region. High-quality surveillance data with laboratory confirmation is important to monitor circulating bacterial meningitis pathogens and design appropriate interventions, but complete testing of all reported cases is often infeasible.