Trends in clinical characteristics and outcomes of all critically ill COVID-19 adult patients hospitalized in France between March 2020 and June 2021: a national database study.

Introduction: Studies regarding coronavirus disease 2019 (COVID-19) were mainly performed in the initial wave, but some small-scale data points to prognostic differences for patients in successive waves. We therefore aimed to study the impact of time on prognosis of ICU-admitted COVID-19 patients.

Method: We performed a national retrospective cohort study, including all adult patients hospitalized in French ICUs from March 1, 2020 to June 30, 2021, and identified three surge periods.

Impact of ICU transfers on the mortality rate of patients with COVID-19: insights from comprehensive national database in France.

Background: The first wave of the COVID-19 pandemic confronted healthcare systems around the world with unprecedented organizational challenges, particularly regarding the availability of intensive care unit (ICU) beds. One strategy implemented in France to alleviate healthcare pressure during the first COVID-19 wave was inter-hospital transfers of selected ICU patients from overwhelmed areas towards less saturated ones. At the time, the impact of this transfer strategy on patient mortality was unknown.

Factors associated with inappropriate use of emergency departments: findings from a cross-sectional national study in France.

Background: Inappropriate visits to emergency departments (EDs) could represent from 20% to 40% of all visits. Inappropriate use is a burden on healthcare costs and increases the risk of ED overcrowding. The aim of this study was to explore socioeconomic and geographical determinants of inappropriate ED use in France.

Recurrence and mortality 1 year after hospital admission for non-fatal self-harm: a nationwide population-based study.

Aims: A large number of people present each day at hospitals for non-fatal deliberate self-harm (DSH). Examination of the short-term risk of non-fatal recurrence and mortality at the national level is of major importance for both individual medical decision-making and global organisation of care.

Methods: Following the almost exhaustive linkage (96%) of two national registries in France covering 45 million inhabitants (i.

The French Emergency National Survey: A description of emergency departments and patients in France.

Introduction: Some major changes have occurred in emergency department (ED) organization since the early 2000s, such as the establishment of triage nurses and short-track systems. The objectives of this study were to describe the characteristics of French EDs organization and users, based on a nationwide cross-sectional survey.

Methods: The French Emergency Survey was a nationwide cross-sectional survey.

[Characteristics of patient management in emergency departments].

A national survey carried out in France in June 2013 studied for the first time all emergency department attendances over a 24-hour period. It enables patients' pathways through the emergency department to be described in detail, from their conditions of arrival through to the follow-up care downstream of their attendance.

Did case-based payment influence surgical readmission rates in France? A retrospective study.

Objectives: To determine whether implementation of a case-based payment system changed all-cause readmission rates in the 30 days following discharge after surgery, we analysed all surgical procedures performed in all hospitals in France before (2002-2004), during (2005-2008) and after (2009-2012) its implementation.

Setting: Our study is based on claims data for all surgical procedures performed in all acute care hospitals with >300 surgical admissions per year (740 hospitals) in France over 11 years (2002-2012; n=51.6 million admissions).

Antibiotic therapy duration for prosthetic joint infections treated by Debridement and Implant Retention (DAIR): Similar long-term remission for 6 weeks as compared to 12 weeks.

Background: The required duration of antibiotic treatment for prosthetic joint infections (PJI) with debridement and retention of the implant (DAIR procedure) is unknown.

Methods: Multicenter retrospective study emphasizing the duration of antibiotic therapy in patients treated with by DAIR.

Results: We included 87 hip or knee PJI episodes in 87 patients from three university hospitals in France and Switzerland.

[Evaluation of the metrological quality of the medico-administrative data for perinatal indicators: A pilot study in 3 university hospitals].

Background: In order to assess public health policies for the perinatal period, routinely produced indicators are needed for the whole population. In France, these indicators are used to compare the national public health policy with those of other European countries. French administrative and medical data (PMSI) are straightforward and reliable and may be a valuable source of information for research.

[Quality of perinatal statistics from hospital discharge data: comparison with civil registration and the 2010 National Perinatal Survey].

Objective: To compare hospital discharge data (PMSI) with data in the reference databases: vital statistics and National Perinatal Surveys (NPS) for the principal perinatal indicators.

Methods: Data concerning hospitalizations for delivery and childbirth were extracted from the PMSI 2010 database. The exhaustiveness was assessed by comparing discharge data with data from birth certificates.

Two consecutive deep sinus tract cultures predict the pathogen of osteomyelitis.

Objectives: The value of non-bone microbiological cultures in the diagnosis of osteomyelitis with sinus tract is not clear. We aimed to establish the concordance between deep sinus tract cultures and bone cultures in cases of osteomyelitis with a cutaneous fistula.

Methods: This was a non-randomized, prospective diagnostic trial at the Orthopedic Service of the University Hospital of Geneva.

Accuracy of bedside glucometry in critically ill patients: influence of clinical characteristics and perfusion index.

Objectives: To determine the accuracy of bedside glucose strip assay on capillary blood and on whole blood and to identify factors predictive of discrepancies with the laboratory method.

Patients And Methods: We conducted a prospective 3-month (July 1-September 30, 2003) study in 85 consecutive patients who required blood glucose monitoring. Values obtained with a glucose test strip on capillary blood and on whole blood were compared with those obtained in the laboratory during serial blood sampling (up to 4 samples per patient).

Initial efficacy and tolerability of early enteral nutrition with immediate or gradual introduction in intubated patients.

Objective: To compare the initial (D7) calorie intake and tolerability of two early enteral nutrition protocols in which the optimal flow rate was introduced either immediately or gradually.

Design: Open, prospective, randomized study.

Setting: Two medical-surgical intensive care units.

[Antiretroviral therapy in critically ill patients: a French national study].

Settings: The HIV-positive population is still increasing because the incidence of the disease remains high while the effectiveness of highly active antiretroviral therapy (HAART) has dramatically reduced mortality. HIV infected patients have an increased life expectancy and are more readily admitted to intensive care units.

Method: We conducted a nation-wide comparative study in France of how these patients are managed by ICU specialists, on one hand, and HIV specialists, on the other, to better understand the use of antiretroviral therapy in critically ill patients.

Acute poststernotomy mediastinitis managed with debridement and closed-drainage aspiration: factors associated with death in the intensive care unit.

Objective: The purpose of the study is to describe an intensive care unit's experience in the treatment of poststernotomy mediastinitis and to identify factors associated with intensive care unit death.

Methods: Over a 10-year period, 316 consecutive patients with mediastinitis occurring less than 30 days after sternotomy were treated in a single unit. First-line therapy was closed-drainage aspiration with Redon catheters.

High versus standard dose vancomycin for osteomyelitis.

It is important to identify the optimal dosage and best method of infusion of parenteral vancomycin to be used over a several week period for the treatment of osteomyelitis. A retrospective study was undertaken to compare a high dose vancomycin treatment (HD: 40 mg/kg/d) with a standard dose treatment (SD: 20 mg/kg/d), and also to compare the modality of infusion using either intermittent vancomycin infusion (IVI) or continuous vancomycin infusion (CVI). 89 patients with Gram-positive cocci osteomyelitis requiring vancomycin treatment were followed, and the outcome and therapeutic safety were compared.

High dose vancomycin for osteomyelitis: continuous vs. intermittent infusion.

Objectives: To compare the efficacy, ease of use and safety of intermittent vancomycin infusion (IVI) and continuous vancomycin infusion (CVI) in high-dose therapy of osteomyelitis.

Methods: Forty-four patients with an osteomyelitis requiring vancomycin for more than 4 weeks were prospectively included, 21 receiving IVI and 23, CVI. The target serum concentration of vancomycin was 20-25 mg/L.

[Prospective assessment of information programme for blood transfusion in critical care patients].

Objectives: Assessment of oral and written information programme for blood transfusion in critical care patients and study of factors associated with the biological follow-up.

Study Design: Prospective study in one intensive care unit.

Patients And Methods: All blood recipients in 2000 were orally informed of transfusion process.

Effect of vancomycin therapy for osteomyelitis on colonization by methicillin-resistant Staphylococcus aureus: lack of emergence of glycopeptide resistance.

Background: In treating orthopedic infections, the long-term impact of vancomycin therapy on colonization by methicillin-resistant Staphylococcus aureus (MRSA) and the emergence of vancomycin-intermediate S. aureus is unknown.

Design: Prospective surveillance of the effect of long-term vancomycin therapy on colonization by MRSA and the emergence of vancomycin-intermediate S.

Relationship between levels of indinavir in hair and virologic response to highly active antiretroviral therapy.

Background: Suboptimal levels of antiretroviral drugs result in virologic failure in HIV-infected patients treated with highly active antiretroviral therapy (HAART).

Objective: To assess the relationship between levels of indinavir in hair and virologic outcome.

Design: Cross-sectional study.

Anal fissure and thrombosed external hemorrhoids before and after delivery.

Purpose: Thrombosed external hemorrhoids and anal fissures are common and are responsible for severe discomfort during childbirth. However, the real incidence of these lesions is unknown. The aim of our study was to evaluate their incidence and the risk factors for these lesions during childbirth.

Diagnosis and follow-up of infections in intensive care patients: value of C-reactive protein compared with other clinical and biological variables.

Objective: To evaluate diagnostic and prognostic values of C-reactive protein (CRP) dosage in critically ill patients.

Design: Prospective, observational study.

Setting: Medical intensive care unit (ICU) in a university hospital.